The Clarke Group
BC Ph: 617.552.3624
E-mail: clarke@bc.edu
Research in Dr. Clarke's laboratory focuses on the
interactions of transition metal ions with biologically important molecules.
The new knowledge learned is applied to the development of
metallopharmaceuticals. For example, glutathione, which occurs in millimolar
concentrations in cells, can either facilitate or hinder DNA binding by
transition metal anticancer agents. Transferrin, which transports Fe3+ in the blood, also serves as a Trojan horse to
provide some metal ions, such as Ru3+,
preferential entry into tumor cells. Some ruthenium complexes appear to be
selectively toxic to tumors by being activated by reduction by the tumor itself
to bind to nucleic acids. Ruthenium complexes induce new modes of hydrolysis
and oxidation, which may cut or otherwise damage DNA. The paramagnetism of RuIII also affects the NMR resonances of coordinated
nucleotides so as to probe molecular orbital interactions. Applying sensitive
electrochemical techniques to Ru-DNA adducts reveals that this metal can
migrate within the DNA as a function of its oxidation state. Such interactions
point toward the development of new transition metal agents bound to
transferrin and then activated by the tumor to interfere with its DNA
metabolism and possibly induce cell death by apoptosis.
Metallonitrosyls
can be used as prodrugs for the in vivo release of nitric oxide, which exhibits
many functions in the body including those as: a neurotransmitter, an enzyme
activant, and a cytotoxic agent. Dr. Clarke's laboratory is now engaged in the
synthesis of new complexes that should release NO in vivo and so possibly
affect the biological activities mediated by this molecule, particularly those
involving short term memory in the hippocampal section of the brain.
Earlier work in Dr.
ClarkeÕs laboratory also involved the coordination of ruthenium ammine ions to
coenzymes such as flavins and vitamin-C.
Publications
1. Haney,
W.; Clarke, M.J., ŅCheating on Tests:
Prevalence, Detection, and Implications for Online TestingÓ, book
chapter in Psychological
Perspectives on Academic Cheating, Anderman, E.A. and Murdock, T., eds, 2007, Elsevier, San Diego.
2. Lopes,
L. G. F., Castellano, E. E., Ferreira, A. G., Davanzo, C. U., Clarke, M. J.,
& Franco, D. W., ŅReactivity of trans-[Ru(NH3)4P(OEt)3NO]X3
(X = PF6-, CF3COO-): modulation of
the release of NO by the trans-effectÓ, 2005, Inorganica Chimica Acta, 358(10), 2883-2890.
3. Clarke,
M. J., "Ruthenium Metallopharmaceuticals", Coord. Chem. Rev., 2002, 232, 69-93; updated 2003, 236, 207-231.
4. Marcondes,
Fabiana G.; Ferro, Alessander A.; Souza-Torsoni, Adriana; Sumitani, Marie; Clarke,
Michael J.; Franco, Douglas W.; Tfouni, Elia; Krieger, Marta H. ŅIn vivo effects of the controlled NO
donor/scavenger ruthenium cyclam complexes on blood pressureÓ, Life Sciences, 2002, 70, 2735-2752.
5. Lopes,
Luiz G.F.; Wieraszko, A.,
El-Sherif, Y.; Clarke, Michael J., "Trans-Labilization of Nitric Oxide in RuII Complexes by C-Bound
Imidazoles", Inorganica Chimica Acta, 2001, 312,
15-22.
6. Frasca,
D.R.; Gehrig, L.E.; Clarke, M.J., ŅCellular Effects of Transferrin Coordinated
to [Cl(NH3)5Ru]Cl2 and cis-[Cl2(NH3)4Ru]Cl.Ó J.
Inorg. Biochem., 2001, 83, 139-149.
7. Wieraszko,
A.; Clarke, M.J.; Lang, D.R.; Lopes, L.G.F.; Franco, D. W., "The Influence
of NO-Containing Ruthenium Complexes on Mouse Hippocampal Evoked Potentials in
vitro", Life Sciences 2001, 68, 1535-1544.
8. LaChance-Galang,
K.J.; Maldonado, I.; M. Gallagher, M.L.; Jian, W.; Prock, A.; Galang, R.D.;
Chaklos, J.; Clarke, M.J., "Terpsichorean Movements of
Pentaammineruthenium on Pyrimidine and Isoytosine Ligands", Inorganic
Chemistry, 2001, 40, 485-492
9. Lang,D.R.;
Davis, J.A.; Lopes, L.G.F.; Ferro, A.A.; Vasconcellos, L.C.G.; Franco, D.W.;
Tfouni, E.; Wieraszko, A. and Clarke, M.J., "A Controlled NO-Releasing
Compound: Synthesis, molecular structure, spectroscopy, electrochemistry, and
chemical reactivity of (R,R,S,S)trans-[RuCl(NO)(cyclam)]2+
(1,4,8,11-tetraazacyclotetradecane)", Inorganic Chemistry, 2000, 39, 2294-2300.
10.
Frasca., D.R; Clarke, M.J., "Alterations in the Binding
of [Cl(NH3]5RuIII]2+ to DNA by
Glutathione: Reduction, Autoxidation, Coordination, and Decomposition", Journal
of the American Chemical Society 1999,
121, 8523-8532.
11. Clarke, M. J.,
Zhu, F., Frasca, D.,
"Non-Platinum Chemotherapeutic Metallopharmaceuticals," Chemical Reviews 1999, 99, 2511-2533.
12. Zhao, M.; Clarke,
M. J., "Trans-Pyridine Tetraammine
Complexes of RuII and RuIII with N7-Coordninated Purine
Nucleosides", Journal of Biological Inorganic Chemistry 1999, 4, 318-324.
13. Zhao, M.; Clarke,
M. J., "Effects of Trans-Pyridine
Ligands on the Binding and Reactivity of RuII
and RuIII Ammine Complexes
Coordinated to Guaninek7 on DNA," Journal of Biological Inorganic
Chemistry 1999, 4, 325-340.
14. Clarke, M.J.,
"Ruthenium in Biology: DNA
Interactions" in Electron Transfer Reactions, ACS Symposium Series, 1997,
Isied, S., ed. Ch. 21, pp. 349-365.
15. Rodriguez-Bailey,
V.M.; LaChance-Galang, K.J.; Doan, P.E.; Clarke, M.J., "1H and 31P NMR and EPR of Pentaammineruthenium(III)
Complexes of Endocyclically Coordinated Nucleotides, Nucleosides and Related
Heterocyclic Bases. Autoxidation
of [(GuanosinekN7)(NH3)5RuIII]. Crystal Structure of [7MeGuakN9(NH3)5Ru]Cl3„3H2O.Ó,
Inorganic Chemistry, 1997,
36, 1873-1883.
16. Rodriguez-Bailey,
V.M.; Doan, P.E.; Clarke, M.J., 1H
and 31P NMR of
Pentaammineruthenium(III) Complexes of Exocyclically-Coordinated Adenine and
Cytosine Ligands. Evidence for
Rotamers with Distinct AciditiesÓ, Inorganic
Chemistry, 1997, 36, 1611-1618.
17.
Frasca., D.; Ciampa, J.; Emerson, J.; Umans, R.S.; Clarke,
M.J., "Effects of Hypoxia and Transferrin on Toxicity and DNA Binding of Ruthenium Antitumor Agents
in HeLa Cells", Metal-Based Drugs, 1996,
3, 197-209.
18.
LaChance-Galang, K.J.; Zhao, M.; and Clarke, M.J.,
"Disproportionation of [(py)(NH3)4RuIII]
at the N7 of Guanine Nucleosides Severs the N-Glycosidic Bond, Inorg. Chem. 1996, 35, 6021-6026.
19. Clarke, M.J.;
Bailey, V.; Doan, P.; Hiller, C.; LaChance-Galang, K.J. ; Daghlian, H.; Mandal, S.; Bastos, C. M.; Lang, D., "1H NMR, EPR, UV-Visible
and Electrochemical Studies of Imidazole Complexes of Ru(III). Crystal Structures of cis-[(Im)2(NH3)4RuIII]Br3
and [(1MeIm)6RuII]Cl2„2H2O", Inorg. Chem. 1996, 35, 4896-4903.
20. Clarke, M.J. and
Stubbs, M., "Interactions of Metallopharmaceuticals with DNA", Metal
Ions in Biological Systems, 1996,
32, 727-780.
21. LaChance-Galang,
K.J.; Doan, P.E.; Clarke, M.J.; Rao, U.;
Yamano, A. Hoffman, B. M., "EPR and NMR Spectra as Probes of
Spin-Density Distributions in Heterocyclic Ligands Coordinated in trans-[L(Im)(NH3)4RuIII]: Implications for Long Range Electron
Transfer. Crystal Structure of trans-[(Im)2(NH3)4Ru]Cl3„H2O"Journal
of the American Chemical Society, 1995,
117, 3529-3538.
22. Clarke, M.J. and
Limauro, S., "Metal-Containing Anticancer Agents", Handbook on
Metal-Ligand Interactions in Biological Fluids, Bioinorganic Chemistry, Vol. 2., Guy Berthon, editor, 1995, Marcel Dekker,
New York, pp. 1010-1019.
23. Emerson, J.;
Clarke, M.J.; Ying, W-L.; Sanadi, D.R., "The Component of "Ruthenium
Red" Responsible for Inhibition of Mitochondrial Calcium Ion
Transport. Spectra,
Electrochemistry and Aquation Kinetics. Crystal Structure of µ-O-[(HCO2)(NH3)4Ru]2Cl3", J. Am. Chem. Soc., 1993,
115, 11799-11805.
24. Clarke, M.J.,
"Ruthenium Complexes:
Potential Roles in Anticancer Pharmaceuticals", in "Metal
Complexes in Cancer Chemotherapy", Keppler, B.K., ed., VCH Publishing House,
Heidelberg, 1993, pp. 129-156.
25. Johnson, A.;
O'Connell, L. and Clarke, M.J., "N7 and C8 Coordinated Purine Complexes of [(NH3)5OsIII].
Crystal Structures of 7-[9MeHyp(NH3)5Os]Cl3„H2O and 8-[1,3,7Me3Xan(NH3)5Os]Cl3„2H2O", Inorganica Chimica Acta, 1993, 210, 151-157.
26. Clarke, M.J. and
Gaul, J.B., "Chemistry Relevant to the Biological Effects of Nitric Oxide
and Metallonitrosyls", Structure and Bonding, 1993, 81,
147-181.
27. Lu, J.; Hiller,
C.D. and Clarke, M.J., "Synthesis and Electrochemistry of µ-Oxo Technetium
Complexes with Bipyridine and Halide Ligands. Crystal Structures of µ-O-[X(bpy)2Tc]2X2„bpy (X = Cl, Br) and µ-O-[Cl(phen)2Tc]2Cl2", Inorganic Chemistry, 1993, 32, 1417-1423
28. McNamara, M.;
Clarke, M.J. "Coordination of Pentaammineruthenium to RNA: Spectra, Equilibria, Kinetics and
Electrochemistry", Inorganica
Chemica Acta, 1992, 195, 175-185.
29. Clarke, M.J.; Lu,
Jun, "Synthesis and Spectra of cis-[NCl(phen)2Tc]Cl„H2O
and cis-[NCl(phen)2Tc]PF6 and Considerations of Their Structural
Distortions", Inorganic Chemistry, 1992, 31,
2476-2480.
30. Lu, J. and Clarke,
M.J., "Modulation of Tc-NX (X = O,S) Bonds by ¹-Acceptor Ligands. Comparison of the Crystal Structures of
cis–[(SN)Cl(phen)2Tc]PF6
and cis–[(ON)(H3N)(phen)2Tc](PF6)„(CH3)2CO", Journal of the
Chemical Society, Dalton Transactions, 1992,
1243-1248.
31. Ying, W-L.;
Emerson, J.; Clarke, M.J.; Sanadi, D.R., "Inhibition of Mitochondrial Ca2+ Transport by an Oxo-bridged Dinuclear
Ruthenium Ammine Complex", Biochemistry, 1991, 30, 4949-4952.
32. Lu, J.; Clarke,
M.J., "Sulfur Atom Transfer with Reduction of a [TcVI=N]3+ Core to a [TcI–N=S]2+ Core. Crystal Structure of mer-[Cl2(SN)(4-Picoline)3Tc]." Inorganic
Chemistry, 1990, 29, 4123-26.
33. Lu, J.; Clarke,
M.J., "Synthesis and Reaction Mechanisms of Technetium(V) Complexes with
Nitrogen Heterocycles", in "Technetium and Rhenium in Chemistry and
Nuclear Medicine 3", Nicolini, M.; Bandoli, G.; Mazzi, U. (ed), Raven
Press, NY, 1990, 23-29.
34. Lu, J.; Yamano,
A.; Clarke, M.J., "Synthesis and Characterization of Technetium(III)
Complexes with Nitrogen Heterocycles by O-Atom Transfer from Oxo-Tc(V) Cores. Crystal Structures of mer-[Cl3(Picoline)3Tc] and mer-[Cl3(Picoline)(PMe2Ph)2Tc]. Electrochemical Parameters for the
Reduction of TcII, TcIII and TcIV." Inorganic Chemistry, 1990, 29, 3483-87.
35. Abelleira, A.;
Galang, R.D.; Clarke, M.J., "Synthesis and Electrochemistry of Pterins
Coordinated to Tetraammineruthenium(II)", Inorganic Chemistry, 1990, 29, 633-639.
36. Pell, S.D.;
Sherban, M.M.; Tramontano, V.; Clarke, M.J., "Synthesis of cis-[Cl2(NH3)4Ru]Cl2 and cis-[Br2(NH3)4Ru]Br2", Inorganic Synthesis, 1989, 26, 65-68.
37. Clarke, M.J.,
"Ruthenium Chemistry Pertaining to the Design of Anticancer Agents",
in "Ruthenium and other Non-Platinum Metal Complexes in Cancer Chemotherapy",
Volume 10 of Progress in Clinical Biochemistry and Medicine, M.J. Clarke, editor, Springer-Verlag, Heidelberg,
1989, pp. 25-39.
38. Lu, Jun; Clarke,
M.J., "Substitution Kinetics of trans-[O2(py)4Tc]+,
py = pyridine, picoline, and lutidine", Inorganic Chemistry, 1989, 28, 2315-19.
39. Gariepy, K.C.;
Curtin, M.A.; Clarke, M.J., "Autoxidation of Pentaammineruthenium(III)
Nucleoside Complexes: Xanthine
Oxidase Activity in a Simple Compound without Oxo Atom Transfer", Journal of the American Chemical Society, 1989, 111, 4947-52.
40. Marx, K.A.;
Kruger, R.; Clarke, M.J. Molecular and Cellular Biochemistry 1989, 86, 155-162. "Binding
of the Transition Metal Ion [(H2O)(NH3)5Ru]2+ to Nucleosomal and Internucleosomal
DNA."
41. Lu, Jun; Clarke,
M.J., "Dinuclear Formation, Oxygen Atom Transfer and Intramolecular
Coordination Isomerization in Oxo-Technetium Complexes", Inorganic
Chemistry 1988, 27,
4761-4766.
42. Clarke, M.J.;
Kastner, M.E.; Podbielski, L.A.; Fackler, P.H.; Schreifels, J.; Meinken, G.;
Srivastava, S.C., "Low Symmetry, Mixed-Valent, µ-Oxo Technetium Complexes
with Pyridine and Halide Ligands",
Journal of the American Chemical Society 1988, 110,
1818-1827.
43. Bryan, D.M.; Pell,
S.D.; Kumar, R.; Clarke, M.J., Rodriguez, V.; Sherban, M., Charkoudian, J.,
"Stable Pentaammineruthenium(III) Complexes of Reductic Acids: Synthesis, Linkage Isomers and
Autoxidation Kinetics" Journal
of the American Chemical Society 1988,
110, 1498-1506.
44. Clarke, M.J.;
Galang, R.G.; Rodriguez, V.M.; Kumar, R.; Pell, S.; Bryan, D.M., "Chemical
Considerations in the Design of Ruthenium Anticancer Agents", in
"Proceedings of the 5th International Symposium on Platinum Compounds in
Cancer Chemotherpy", M. Nicolini, editor, Kluwer Publishing, Boston, 1987, pp. 582-600.
45. Clarke, M.J. and
Podbielski, L., "Technetium", in the "Handbook on the Toxicity
of Inorganic Compounds", Seiler, H.G. and Sigel, H., Eds., Marcel Dekker,
Inc., NY, 1988, 665-667.
46. Clarke, M.J. and
Podbielski, L., "Medical Diagnostic Imaging with Complexes of 99mTc", Coord. Chem. Rev., 1987, 78, 253-331.
47. Clarke, M.J.;
Podbielski, L.; Kastner, M.E.; Fackler, P.H., "Oxo Technetium Complexes
with Pyridine and Halide Ligands", in "Technetium in Chemistry and
Nuclear Medicine", Nicolini, M.; Bandoli, G.; Mazzi, U., Ed., 1987, Raven Press, New York, pp. 29-35.
48. Lalibert, J.F.;
Sun, I.L.; Crane, F.L; Clarke, M.J.,
"Ruthenium Ammine Complexes as Electron Acceptors for Growth
Stimulation by Plasma Membrane Electron Transport", Journal of
Bioenergetics and Biomembranes 1987,
19, 69-81.
49. Kastner, M.E.;
Fackler, P.H.; Charkoudian, J.; Podbielski, L.; Charkoudian, J.; Clarke, M.J., "A Dissymmetric m-Oxo Technetium Complex", Inorganica
Chemica Acta, 1986, 114, L11-15.
50. Clarke, M.J.;
Jansen, B.; Marx, K.A.; Kruger, R., "Biochemical Effects of Binding [(H2O)(NH3)5RuII]2+ to DNA and Oxidation to [(NH3)5RuIII]n-DNA", Inorganica Chemica Acta,
1986, 124, 13-28.
51. Margalit, R.;
Gray, H.B.; Podbielski, L.; Clarke, M.J., "Chemical and Biological
Properties of Pentaammineruthenium-Bleomycin Complexes", Chemico-Biological
Interactions, 1986, 59, 231-245.
52. Clarke, M.J.,
"The Chemistry of Ruthenium Compounds in Potential Anticancer Agents"
in "Precious Metals 1985:
Proceedings of the Ninth International Precious Metals Conference",
E.E. Zysk and J.A. Bonucci,
Eds., Int. Precious Metals
Inst., Allentown, PA, 1986, 369-386.
53. Kastner, M.E.;
Fackler, P.H.; Lindsay, M.J.; Clarke, M.J., "Synthesis and Structure of trans-[O2(Im)4Tc]Cl.2H2O, trans-[O2(1-meIm)4Tc]Cl.3H2O and Related Compounds", Inorganica
Chimica Acta, 1985, 109, 39-49.
54. Kastner, M.E.;
Fackler, P.H.; Clarke, M.J.; Deutsch, E., "Synthesis and Structure of
trans-[O2(4-TBP)4Tc]+ (TBP = 4-tert-butylpyridine) and Related Complexes", Inorganic
Chemistry, 1984, 23, 4683-4688.
55. Fackler, P.H.;
Kastner, M.E.; Clarke, M.J., "Synthesis, Spectra and Structure of af-dibromo-b-ethoxo-d-oxo-ce-bis(4-nitropyridine)technetium(V)
and Related Complexes", Inorganic Chemistry, 1984, 23, 3968-3972.
56. Pell, S.J.;
Salmonsen, R.; Abelliera, A.; Clarke, M.J., "Induced Electron Transfer in
Ammineruthenium Catechol and Quinone Complexes", Inorganic Chemistry, 1984, 23, 385-387.
57. Benecky, M.J.;
Dowling, M.G.; Clarke, M.J.; Spiro, T.G., "Resonance Raman Spectra and
Structure of Flavins Bound to [(NH3)5Ru(II)]", Inorganic Chemistry, 1984, 23, 865-869.
58. Clarke, M.J.,
Morrissey, P.E., "Nucleoside Oxidation and Hydrolysis of a
Metallonucleoside Complex", Inorganica Chimica Acta, 1984, 80, L69-70.
59. Clarke, M.J.,
"Electrochemical Effects of Metal Ion Coordination to Non-Innocent, Biologically
Important Ligands", Comments in Inorganic Chemistry, 1984, 3, 131-151.
60. Clarke, M.J.,
"Ruthenium Anticancer Agents and Relevant Reactions of Ruthenium-Purine
Complexes" in "Chemistry and Biochemistry of Platinum, Gold and Other
Chemotherapeutic Agents", Lippard, S.J., Ed., ACS Symposium Series #209,
American Chemical Society, Washington, D.C., 1983, pp. 335-354.
61. Dowling, M.G. and
Clarke, M.J., "Electrochemistry of Metalloflavin Complexes in
Dimethylformamide", Inorganica Chemica Acta, 1983, 78,
153-160.
62. Clarke, M.J.;
Kastner, M.E.; Lindsay, M.J., "Synthesis Structure and Chemistry of trans-[O2(en)2Tc(V)]+",
Inorganic Chemistry, 1982,
21, 2037-2040.
63. Clarke, M.J.;
Perpall, H.; Coffey, K.E., "Analysis of the Hydrolysis of
Metallonucleoside Complexes by
HPLC", Analytical Biochemistry, 1982,
122, 404-411.
64. Clarke, M.J. and
Dowling, M.G., "Electrochemistry of N5-
Metallated Flavins in Aqueous and Nonaqueous Media" in "Proceedings
of the Seventh International Flavin Symposium", Massey, V. and Williams, C.
Eds., Elsevier, NY, 1982, pp. 579-583.
65. Clarke, M.J., and
Fackler, P.H., "The Chemistry of Technetium: Toward Improved Diagnostic Agents", Structure and Bonding, 1982, 50, 57-78.
66. Barr, R.; Crane,
F.L.; Clarke, M.J., "Ruthenium Complexes as Electron Acceptors in
Photosystem I of Spinach Chloroplasts", Proc. Indiana Acad. Sci., 1982, 91, 114-119.
67. Kastner, M.E.;
Coffey, K.F.; Clarke, M.J.; Edmonds, S.E.; and Eriks, K., "Structural
Correlations and Metal Ion Movement in Stable Pentaammineruthenium Complexes",
Journal of the American
Chemical Society, 1981, 103, 5747-5752.
68. Clarke, M.J. and
Dowling, M.G., "Cyclic Voltammetry Studies of Metalloflavin Complexes in
Aqueous Solution", Inorganic Chemistry,
1981, 20, 3506-3514.
69. Clarke, M.J.;
Dowling, M.G.; Garafalo, A.F.; Brennan, T.F., "Structural and Electronic
Effects Resulting from Metal Flavin Ligation", Journal of Biological
Chemistry, 1980, 255, 3472-3481.
70. Clarke, M.J.,
"Electrochemistry of Transition Metal Complexes with Flavin Nucleosides
and Their Constituent Bases", Reviews in Inorganic Chemistry, 1980, 2, 27-52.
71. Clarke, M.J.,
"Mutagenicity and Modes of Metal Binding to Nucleic Acids", Inorganic Chemistry,
1980, 19, 1103.
72. Clarke, M.J.,
"Oncological Implications of the Chemistry of Ruthenium", Metal
Ions in Biological Systems, 1980, 11, 231-283.
73. Clarke, M.J.,
"The Potential of Ruthenium in Anticancer Pharmaceuticals: in
"Inorganic Chemistry in Biology and Medicine", Martell, A.E., Ed.,
ACS Symposium Series #190, American Chemical Society, Washington, D.C., 1980, pp. 157-180.
74. Clarke, M.J.;
Bitler, S.; Rennert, D.; Buchbinder, M.; Kelman, A.D., "Reduction and
Subsequent Binding of Ruthenium Ions Catalyzed by Subcellular Components",
Journal of Inorganic
Biochemistry, 1980, 12, 79-87.
75. Yasbin, R.E.; Matthews,
C.R.; Clarke, M.J., "Mutagenic and Toxic Effects of Ruthenium", Chemical
and Biological Interactions, 1980,
30, 355-365.
76. Srivastava, S.C.;
Richards, P.; Meinken, G.E.; Som, P.; Atkins, H.L.; Larson, S.M.; Grunbaum, A.;
Rasey, J.S.; Dowling, M.G. and Clarke, M.J., "Evaluation of Radiolabaeled
Ruthenium Compounds as Tumor Localizing Agents", in
"Radiopharmaceuticals II", Sorensen, J.A., Ed., Society of Nuclear
Medicine, New York, 1979, pp. 265-269.
77. Clarke, M.J.;
Dowling, M.G.; Brennan, T.F.; Garafalo, A.F., "Electrochemistry, Spectra
and Synthesis of a Stable Enantiomeric Metalloflavin Complex", Journal
of the American Chemical Society, 1979, 101, 223-225.
78. Clarke, M.J.;
Buchbinder, M.; Kelman, A.D., "Binding of Pentaammineruthenium(III) to
Double-Helical and Single-Stranded DNA", Inorganica Chemica Acta, 1978, 27, L87-L88.
79. Clarke, M.J.,
"Electrochemistry, Spectra and Synthesis of Pentaammineruthenium Complexes
with Cytidine, Adenosine and Related Ligands", Journal of the American Chemical Society, 1978, 100, 5068-5075.
80. Clarke, M.J.,
"Linkage Isomers of Pentaammineruthenium Hypoxanthine Complexes",
Inorganic Chemistry, 1977, 16, 738-744.
81. Kelman, A.D.;
Clarke, M.J.; Edmonds, S.D.; Peresie, H.J., "Biological Activity of
Ruthenium Purine Complexes", Journal of Clinical Hematology and
Oncology, 1977, 7, 274-288.
82. Clarke, M.J. and
Taube, H., "Nitrogen and Carbon Bound Xanthine Complexes with Ruthenium
Ammines", Journal of the American Chemical Society, 1975, 97, 1397-1403.
83. Krentzien, H.;
Clarke, M.J. and Taube, H., "Crystal Structure of a Compound Featuring
Caffeine Bound at C8 to
Ruthenium(III)", Bioinorganic Chemistry, 1975, 4,
143-151.
84. Clarke, M.J. and
Taube, H., "Pentaammineruthenium-Guanine Complexes", Journal of the American Chemical Society, 1974, 96, 5413-5419.
85. Clarke, M.J. and
Venezky, D.L., "Teflon Mixing Vial for Handling Solids for Infrared
Spectroscopy", Journal of Chemical Education, 1969, 46, 458.
Edited Books
1.
Clarke,
M. J. in "Ruthenium and Other Non-Platinum Metal Complexes in Cancer
Chemotherapy"; Springer-Verlag: Heidelberg, Germany, 1989.
2.
Clarke, M. J. (ed), Less Common Metals in Proteins and Nucleic
Acid Probes, Springer, Heidelberg, 1998.
3.
Clarke, M. J.; Sadler, P. J. Topics in Biological Inorganic
Chemistry 1999, 2, 216. Metallopharmaceuticals II: Diagnosis & Therapy.
4.
Clarke, M. J.; Sadler, P. J. Topics in Biological Inorganic
Chemistry 1999, 1, 200. Metallopharmaceuticals I: DNA Interactions.
Recognitions
and Honors
Professional:
NSF Program Director for Inorganic, Bioinorganic and Organometallic Chemistry,
2001-2004. Program Officer, 1996-7.
Program Director, Nanotechnology in Undergraduate Education, 2002-2004
Co-chair, Metals in Medicine Gordon
Research Conference 2002
NIH Biometallic Study Section Member 1991-1995; 1988-91, 1998-99 ad hoc
Secretary Division of Inorganic Chemistry, American Chemical Society 1995-98
Editor, Structure
and Bonding.
1984-1999,
Editor, Topics
in Bioinorganic Chemistry, 1999-present
Editor, Metal-Based
Drugs, 1992-2000
Whiting Foundation Fellow, 1984
NIH
Young Investigator Grant Award, 1978-1981
Graduate:
Phi Lambda Upsilon, Chemical Honorary Society
Undergraduate: Phi Beta Kappa, Hillebrand Jr. Award, Sigma Xi Award, AIC Medali