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| Publications |
| Seyfried Laboratory |
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| Brain Cancer |
| Kiebish MA , Seyfried TN . 2005. Absence of pathogenic mitochondrial DNA mutations in mouse brain tumors. BMC Cancer. 5:102 |
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| P Mukerjee, LE Abate, TN Seyfried. 2004. Antiangiogenic and proapoptotic effects of dietary restriction on experimental mouse and human brain tumors. Clin Cancer Res.10:5622-5629. |
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| N Seyfried, TM Sanderson, MM El-Abbadi, R McGowan, and P Mukherjee. 2003. Role of glucose and ketone bodies in the metabolic control of experimental brain cancer. Brit. J. Cancer 89: 1375-1382. |
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| P Mukherjee, MM El-Abbadi, JL Kasperzyk, MK Ranes, and TN Seyfried. 2002. Dietary restriction reduces angiogenesis and growth in an orthotopic mouse brain tumour model. Brit. J. Cancer 86:1615-21. |
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| M El-Abbadi, TN Seyfried, AJ Yates, C Orosz, and MC Lee. 2001. Ganglioside Composition and Histology of a Spontaneous Metastatic Brain Tumour in the VM Mouse. Brit. J. Cancer 85:285-292. |
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| TN Seyfried. 2001. Perspectives on brain tumor formation involving macrophages, glia, and neural stem cells. Perspectives in Biology and Medicine 44: 263-282. |
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| MK Ranes, M El-Abbadi, MG Manfredi, P Mukherjee, FM Platt and TN Seyfried. 2001. N-butyldeoxynojirimycin Reduces Growth and Ganglioside Content of Experiemental Mouse Brain Tumours. Brit. J. Cancer 84:1107-1114. |
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| MG Manfredi, S Lim, KP Claffey, and TN Seyfried. 1999. Gangliosides Influence Angiogenesis in an Experimental Mouse Brain Tumor. Cancer Res. 59: 5392-5397. |
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| JA Ecsedy, HC Yohe, AJ Bergeron, and TN Seyfried. 1998. Tumor Infiltating Macrophages Influence the Glycosphingolipid Composition of Mouse Brain Tumors. J. Lipid Res. 39: 2218-2227. |
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Epilepsy |
| SC Heinrichs & TN Seyfried. 2005. Behavioral Seizure Correlates in Animal Models of Epilepsy: A Roadmap for Assay Selection, Data Interpreation and the Search for Casual Mechanisms. Epilepsy & Behavior (In Press) |
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| JG Mantis, NA Centeno, MT Torodova, R McGowan, and TN Seyfried. 2004. Management of multifactorial idiopathic epilepsy in EL mice with caloric restriction and the ketogenic diet: role of glucose and ketone bodies. Nurtr Metab (Lond) 1(1):11. |
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| EL Venit, BD Shepard, and TN Seyfried. 2004. Oxygenation Prevents Sudden Death in Seizure Prone Mice. Epilepsia. 45, 993-996. |
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| MT Torodova, CA Dangler, MG Drage, BJ Sheppard, JG Fox, and TN Seyfried. 2003. Sexual dysfunction and sudden death in epileptic male EL mice: inheritance and prevention with the ketogenic diet. Epilepsia 44:25-31. |
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| AE Greene, MT Torodova , and TN Seyfried. 2003. Perspectives on the metabolic management of epilepsy through dietary reduction of glucose and elevation of ketone bodies. J Neurochem Aug; 86(3): 529-537. |
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| MG Drage, GL Holmes, and TN Seyfried. 2002. Hippocampal neurons and glia in epileptic EL mice. J. Neurocytol. Sep-Nov; 31(8-9):681-92. |
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| AE Greene, MT Todorova, R McGowan, and TN Seyfried. 2001. Caloric restriction inhibits seizure susceptibility in epileptic EL mice by reducing blood glucose levels. Epilepsia 42:1371-1378. |
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| MT Todorova, P Tandon, RA Madore, CE. Stafstrom, and TN Seyfried. 2000. The ketogenic diet inhibits epileptogenesis in EL mice: A genetic model for idiopathic epilepsy. Epilepsia 41: 933-940. (PDF) |
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| MT Todorova, TJ Burwell, and TN Seyfried. 1999. Environmental risk factors for multifactorial epilepsy in EL mice. Epilepsia 40: 1697-1707. (PDF) |
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| TN Seyfried, MT Todorova, MJ Poderycki. 1999. Experimental Models of Multifactorial Epilepsies: The EL Mouse and Mice Susceptible to Audiogenic Seizures. Jasper's Basic Mechanisms of the Epilepsies, Third Edition: Adv. Neurol, Vol. 79. Lippincott Williams & Wilkins, Philadelphia, PA |
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| MJ Poderycki, JM Simoes, MT Todorova, PE Neumann, TN Seyfried.1998. Environmental influences on epilepsy gene mapping in EL mice. J Neurogenet.12: 67-86.(PUBMED) |
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Ganglioside Storage Diseases |
| JL Kasperzyk, A d'Azzo, FM Platt, J Alroy, TN Seyfried. 2005. Substrate reduction reduces gangliosides in postnatal cerebrum-brainstem and cerebellum in GM1 gangliosidosis mice. J Lipid Res. 46(4):744-51 |
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| JL Kasperzyk, MM El-Abbadi, EC Hauser, A d'Azzo, FM Platt, and TN Seyfried. 2004. N-butyldeoxygalactonojirimycin reduced neonatal brain ganglioside content in a mouse model of GM1 gangliosidosis. J.Neurochem 89:645-53. |
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| EC Hauser, JL Kasperzyk, A d'Azzo, and TN Seyfried. 2004. Inheritance of lysosomal acid B-Galactose activity and ganglioside in crosses of DBA/2J and knockout mice. Biochem. Genetics 42(7-8):241-57. (PDF) |
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| V Brigande, FM Platt, and TN Seyfried. 1998. Inhibition of Glycosphinoglipid Biosynthesis does not Impair Growth or Morphogenesis of the Postimplantation Mouse Embryo. J. Neurochem. 70:871-882. |
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