 The
current focus of my research is the implementation of
a stereodivergent strategy towards the total synthesis
of the 5-F2 class of isoprostanes. Beginning with
commercially available furfuryl alcohol all eight enantiomerically
pure members of this family of compounds can be accessed
via ring opening olefin metathesis. Isoprostanes
have been used as markers for oxidative stress in mammalian
cell lines by clinicians. They are thought to
be derived from arachidonic acid, one of the major components
of the cell membrane. A facile and efficient synthesis
of these compounds will facilitate investigations into
the potential cellular targets of these compounds.
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