2014

Shannon, D.A., Banerjee, R., Webster, E.R., Bak, D.W., Wang, C., Weerapana, E. Investigating the Proteome Reactivity and Selectivity of Aryl Halides J. Am. Chem. Soc., 2014, 136, 3330-3.
Zhuang, J., Kuo, C.H., Chou, L.Y., Liu, D.Y., Weerapana, E.*, Tsung, C.K.* Optimized metal-organic-framework nanospheres for drug delivery: evaluation of small-molecule encapsulation. ACS Nano, 2014, 8, 2812–19.
Martell, J., Weerapana, E. Applications of copper-catalyzed click chemistry in activity-based protein profiling. Molecules, 2014, 19, 1378-93. Special Issue on "Bioorthogonal Chemistry"
Wang, C., Weerapana, E., Blewett, M.M., Cravatt, B.F. A chemoproteomic platform to quantitatively map targets of lipid-derived electrophiles. Nature Methods, 2014, 11, 79-85.
Pace, N.J., Weerapana, E. A competitive chemical-proteomic platform to identify zinc-binding cysteines. ACS Chemical Biology, 2014, 9, 651-6.
Couvertier, S.M., Weerapana, E. Cysteine-reactive chemical probes based on a modular 4-amino-piperidine scaffold. MedChemComm, 2014, 5, 358-362.
Shannon D.A., Weerapana, E. Orphan PTMs: Rare, yet functionally important modifications of cysteine. Biopolymers, 2014, 101, 156-164.
2013

Schwaid, A.G.#, Shannon, D.A.#, Ma, J., Slavoff, S.A., Levin, J.Z., Weerapana, E.*, Saghatelian, A.* Chemoproteomic discovery of cysteine-containing human short open reading frames. J. Am. Chem. Soc., 2013, 135, 16750-3.
Child, M.A., Hall C.I., Beck, J.R., Ofori, L.O., Albrow,V.E., Garland, M., Bowyer, P.W., Bradley,P.J., Powers, J.C., Boothroyd, J.C., Weerapana, E., Bogyo, M. Small-molecule inhibition of a depalmitoylase enhances Toxoplasma host-cell invasion. Nat. Chem. Biol., 2013, 9, 651-6.
Lee, B.C., Péterfi, Z., Hoffmann, F.W., Moore, R.E., Kaya, A., Avanesov, A., Tarrago, L., Zhou, Y., Weerapana, E., Fomenko, D.E., Hoffmann, P.R., Gladyshev, V.N. MsrB1 and MICALs Regulate Actin Assembly and Macrophage Function via Reversible Stereoselective Methionine Oxidation. Molecular Cell, 2013, 51, 397-404.
Qian, Y., Martell, J., Pace N.J., Ballard, E.T., Johnson, D.S.*, Weerapana, E*. An isotopically tagged azobenzene-based cleavable linker for quantitative proteomics. ChemBioChem, 2013, 14, 1410-1414.
Banerjee, R., Brown, D.R., Weerapana, E. Recent Developments in the Synthesis of Bioactive 2,4,6-Trisubstituted-1,3,5-Triazines. Synlett, 2013, 24, 1599-1605.
Gu C., Shannon D.A., Colby T., Wang Z., Shabab M., Kumari S., Villamor J.G., McLaughlin C.J., Weerapana E., Kaiser M., Cravatt B.F., van der Hoorn R.A.L. Chemical Proteomics with Sulfonyl Fluoride Probes Reveals Selective Labeling of Functional Tyrosines in Glutathione Transferases. Chemistry & Biology, 2013, 20, 541-548.
Deng X., Weerapana E., Ulanovskaya O., Sun F., Liang H., Ji Q., Ye Y., Fu Y., Zhou L., Li J., Zhang H., Wang C., Alvarez S., Hicks L.M., Lan L., Wu M., Cravatt B.F., He C. Proteome-wide Quantification and Characterization of Oxidation-Sensitive Cysteines in Pathogenic Bacteria. Cell Host Microbe, 2013, 13, 358-70.
Banerjee, R., Pace, N.J., Brown, D.R., Weerapana, E. 1,3,5-Triazine as a Modular Scaffold for Covalent Inhibitors with Streamlined Target Identification. J. Am. Chem. Soc., 2013, 135, 2497-500.
Pace, N.J., Weerapana, E. Diverse functional roles of reactive cysteines. ACS Chemical Biology, 2013, 8, 283-96.
Ramya, T. N. C., Weerapana, E., Cravatt, B. F., Paulson, J. C. Glycoproteomics enabled by tagging sialic acid or galactose terminated glycans. Glycobiology, 2013, 23, 211-21.
2012

ChemBioChem cover, Nov. 5, 2012 Shannon, D. A., Gu, C., McLaughlin, C. J., Kaiser, M., van der Hoorn, R. A. L., Weerapana, E. Sulfonyl Fluoride Analogues as Activity-Based Probes for Serine Proteases. ChemBioChem, 2012, 13, 2327-2330.
(cover article, see right)
Pace, N. J., Pimental, D. R., Weerapana, E.
An Inhibitor of Glutathione S-Transferase Omega 1 that Selectively Targets Apoptotic Cells. Angew. Chem. Int. Ed., 2012, 124, 8490-8493.
Tarrago, L., Kaya, A., Weerapana, E., Marino, S. M., Gladyshev, V. N. Methionine Sulfoxide Reductases Preferentially Reduce Unfolded Oxidized Proteins and Protect Cells from Oxidative Protein Unfolding. J. Biol. Chem., 2012, 287, 24448-24459.
2011

Hall, C., Reese, M., Weerapana, E., Child, M., Bowyer, P., Albrow, V., Heraldsen, J., MacDonald, P. Sandoval, E. D., Ward, G., Cravatt, B. F., Boothroyd, J., Bogyo, M. A chemical genetic screen identifies Toxoplasma DJ-1 as a regulator of parasite secretion and invasion. Proc. Natl. Acad. Sci., 2011, 108, 10568-10573.
Bachovchin, D. A., Zuhl, A. M., Speers, A. E., Wolfe, M. R., Weerapana, E., Brown, S. J., Rosen, H., Cravatt, B., F.. Discovery and optimization of sulfonyl acrylonitriles as selective, covalent inhibitors of protein phosphate methylesterase-1. J. Med. Chem., 2011, 54, 5229-5236.
Ahn, K., Smith, S. E., Liimatta, M. B., Beidler, D., Sadagopan, N., Dudley, D. T., Young, T., Wren, P., Zhang, Y., Swaney, S., Van Becelaere, K., Blankman, J. L., Nomura, D. K., Bhattachar, S. N., Stiff, C., Nomanbhoy, T. K., Weerapana, E., Johnson, D. S., Cravatt, B. F. Mechanistic and pharmacological characterization of PF-04457845: a highly potent and selective FAAH inhibitor that reduces inflammatory and noninflammatory pain. J. Pharmacol. Exp. Ther., 2011, 338, 114-124.
2010

Weerapana, E.*, Wang, C.*, Simon, G.M., Richter, F., Khare, S., Dillon, B.D.M., Bachovchin, D.A., Mowen, K., Baker, D., Cravatt, B.F. Quantitative reactivity profiling predicts functional cysteines in proteomes. Nature, 2010, 468, 790-795.
*These authors contributed equally to this work.
Johnson, D.S., Weerapana, E., Cravatt, B.F. Strategies for discovering and derisking covalent, irreversible enzyme inhibitors. (Review) Fut. Med. Chem. 2010, 2, 949-964.
Wurdak, H., Zhu, S., Aimone, L., Lairson, L.L., Watson, J., Chopiuk, G., Min, K.H., Demas, J., Charette, B., Halder, R., Weerapana, E., Cravatt, B.F., Cline, H.T., Peters, E.C. Zhang, J., Walker, J.R., Wu, C., Zhang, J., Tuntland, T., Cho, C.Y., Shultz, P.G., A small molecule accelerates neuronal differentiation in the adult rat. Proc. Natl. Acad. Sci., 2010, 107, 16542-7.
Ramya, T. N. C., Weerapana, E., Liao, L., Zeng, Y., Tateno, H., Liao, L., Yates, J., Cravatt, B. F., Paulson, J. C. In situ trans ligands of CD22 identified by glycan-protein photocross-linking-enabled proteomics. Mol. Cell. Proteomics. 2010, 9, 1339-51.

2009

Ahn, K., Johnson, D. S., Mileni, M., Beidler, D., Long, J. Z., McKinney, M. K., Weerapana, E., Sadagopan, N., Liimatta, M., Smith, S. E., Lazerwith, S., Stiff, C., Kamtekar, S., Bhattacharya, K., Zhang, Y., Swaney, S., Van Becelaere, K., Stevens, R. C., Cravatt, B. F. Discovery and Characterization of a Highly Selective FAAH Inhibitor that Reduces Inflammatory Pain. Chem. Biol. 2009, 16,411-20.

2008

Weerapana, E., Simon, G. M., Cravatt, B. F. Disparate proteome reactivity profiles of carbon electrophiles. Nat. Chem. Biol. 2008, 4, 405-7.

2007

Chen, M. C., Weerapana, E., Ciepichal, E. Stupak, J., Reid, C.W, Swiezewska, E. and Imperiali, B. (2007) Polysisoprenyl specificity in the Campylobacter jejuni N-linked glycosylation pathway. Biochemistry, 2007, 46, 14342-8.

Weerapana, E., Speers, A. E. and Cravatt, B. F. Tandem orthogonal proteolysis-activity-based protein profiling (TOP-ABPP) - a general method for mapping sites of probe modification in proteomes. Nat. Protocols, 2007, 2, 1414-25.

Hanson, S. R., Hsu, T-L., Weerapana, E., Kishikawa, K., Simon, G. M., Cravatt, B. F. and Wong, C-H. Tailored glycoproteomics and glycan site mapping using saccharide-selective bioorthogonal probes. J. Am. Chem. Soc., 2007, 129, 7266-7.

2006

Glover, K. J.*, Weerapana, E.*, Chen, M. M. and Imperiali B. Direct biochemical evidence for the utilization of UDP-bacillosamine by PglC, an essential glycosyl-1-phosphate transferase in the Campylobacter jejuni N-linked glycosylation pathway. Biochemistry, 2006, 45, 5343-50.
*These authors contributed equally to this work.
Weerapana, E. and Imperiali, B. Asparagine-linked protein glycosylation: From eukaryotic to prokaryotic systems. (Review) Glycobiology, 2006, 16, 91R-101R.

2005

Glover, K. J.*, Weerapana, E.*, Numao, S. and Imperiali, B. Chemoenzymatic synthesis of glycopeptides with PglB, a bacterial oligosaccharyl transferase from Campylobacter jejuni. Chem. Biol., 2005, 12, 1311-5.
*These authors contributed equally to this work.
Weerapana, E., Glover, K. J. and Imperiali, B. Investigating bacterial N-linked glycosylation: synthesis and glycosyl acceptor activity of the undecaprenyl pyrophosphate-linked bacillosamine. J. Am. Chem. Soc., 2005, 127, 13766-7.

Glover, K. J., Weerapana, E. and Imperiali, B. In vitro assembly of the undecaprenylpyrophosphate-linked heptasaccharide for prokaryotic N-linked glycosylation. Proc. Natl. Acad. Sci. U.S.A., 2005, 102, 14255-9.

2003

Weerapana, E. and Imperiali, B. Peptides to peptidomimetics: towards the design and synthesis of bioavailable inhibitors of oligosaccharyl transferase. Org. Biomol. Chem., 2003, 1, 93-9.