Recent Publications:

 

2009

Wang, Qin; Xia, Jiarong; Guallar, Victor; Krilov, Goran; Kantrowitz, Evan R.   Mechanism of thermal decomposition of carbamoyl phosphate and its stabilization by aspartate and ornithine transcarbamoylases.    Abstracts of Papers, 237th ACS National Meeting, Salt Lake City, UT, United States, March 22-26, 2009 (2009).

Coudray, Laetitia; Kantrowitz, Evan R.; Montchamp, Jean-Luc.   Submicromolar phosphinic inhibitors of Escherichia coli aspartate transcarbamoylase.    Bioorganic & Medicinal Chemistry Letters  (2009), 19(3),  900-902.

Stieglitz, Kimberly A.; Xia, Jiarong; Kantrowitz, Evan R.  The first high pH structure of Escherichia coli aspartate transcarbamoylase.    Proteins: Structure, Function, and Bioinformatics  (2009), 74(2), 318-327.

2008

Wang, Qin; Xia, Jiarong; Guallar, Victor; Krilov, Goran; Kantrowitz, Evan R.  Mechanism of thermal decomposition of carbamoyl phosphate and its stabilization by aspartate and ornithine transcarbamoylases. Proceedings of the National Academy of Sciences of the United States of America  (2008), 105(44), 16918-16923.

West, Jay M.; Xia, Jiarong; Tsuruta, Hiro; Guo, Wenyue; O'Day, Elizabeth M.; Kantrowitz, Evan R.   Time Evolution of the Quaternary Structure of Escherichia coli Aspartate Transcarbamoylase upon Reaction with the Natural Substrates and a Slow, Tight-Binding Inhibitor.    Journal of Molecular Biology  (2008),  384(1),  206-218. 

Wang, Qin; Xia, Jiarong; Guallar, Victor; Krilov, Goran; Kantrowitz, Evan R.   Mechanism of thermal decomposition of carbamoyl phosphate and its stabilization by aspartate and ornithine transcarbamoylases.    Proceedings of the National Academy of Sciences of the United States of America, Early Edition  (2008),  1-6.

Rabinowitz, Joshua D.; Hsiao, Jennifer J.; Gryncel, Kimberly R.; Kantrowitz, Evan R.; Feng, Xiao-Jiang; Li, Genyuan; Rabitz, Herschel.  Dissecting Enzyme Regulation by Multiple Allosteric Effectors: Nucleotide Regulation of Aspartate Transcarbamoylase.    Biochemistry  (2008),  47(21),  5881-5888.

Cardia, James P.; Eldo, Joby; Xia, Jiarong; O'Day, Elizabeth M.; Tsuruta, Hiro; Gryncel, Kimberly R.; Kantrowitz, Evan R. Use of L-asparagine and N-phosphonacetyl-L-asparagine to investigate the linkage of catalysis and homotropic cooperativity in E. coli aspartate transcarbamoylase.    Proteins: Structure, Function, and Bioinformatics  (2008), 71(3), 1088-1096.

2007

Stec, Boguslaw; Williams, Mark K.; Stieglitz, Kimberly A.; Kantrowitz, Evan R.   Comparison of two T-state structures of regulatory-chain mutants of Escherichia coli aspartate transcarbamoylase suggests that His20 and Asp19 modulate the response to heterotropic effectors.    Acta Crystallographica, Section D: Biological Crystallography  (2007),  D63(12),  1243-1253.

Wang, Jie; Eldo, Joby; Kantrowitz, Evan R.   Structural Model of the R State of Escherichia coli Aspartate Transcarbamoylase with Substrates Bound.    Journal of Molecular Biology  (2007),  371(5),  1261-1273.

Eldo, Joby; Heng, Sabrina; Kantrowitz, Evan R.  Design, synthesis and bioactivity of novel inhibitors of E. coli Aspartate Transcarbamoylase.    Abstracts of Papers, 234th ACS National Meeting, Boston, MA, United States, August 19-23, 2007  (2007).

Eldo, Joby; Heng, Sabrina; Kantrowitz, Evan R.  Design, synthesis, and bioactivity of novel inhibitors of E. coli aspartate transcarbamoylase.    Bioorganic & Medicinal Chemistry Letters  (2007), 17(7),  2086-2090.

Fetler, Luc; Kantrowitz, Evan R.; Vachette, Patrice. Direct observation in solution of a preexisting structural equilibrium for a mutant of the allosteric aspartate transcarbamoylase. Proceedings of the National Academy of Sciences of the United States of America  (2007),  104(2),  495-500.

2006

Wang, Jie; Kantrowitz, Evan R.  Trapping the tetrahedral intermediate in the alkaline phosphatase reaction by substitution of the active site serine with threonine.    Protein Science  (2006),  15(10),  2395-2401.

Eldo, Joby; Cardia, James P.; O'Day, Elizabeth M.; Xia, Jiarong; Tsurata, Hiro; Kantrowitz, Evan R. N-phosphonoacetyl-L-isoasparagine a potent and specific inhibitor of Escherichia coli aspartate transcarbamoylase.  Journal of Medicinal Chemistry  (2006),  49(20),  5932-5938.

Heng, Sabrina; Stieglitz, Kimberly A.; Eldo, Joby; Xia, Jiarong; Cardia, James P.; Kantrowitz, Evan R. T-state Inhibitors of E. coli Aspartate Transcarbamoylase that Prevent the Allosteric Transition.    Biochemistry  (2006),  45(33),  10062-10071. 

 

Full Publication List