Research Publications:

 

94.

"Ni-Catalyzed Enantioselective Conjunctive Coupling with C(sp3) Electrophiles: A Radical-Ionic Mechanistic Dichotomy" G. J. Lovinger, and J. P. Morken, J. Am. Chem. Soc. Just Accepted. doi: 10.1021/jacs.7b10519.

GJL

 

 
 

93.

"Ni-Catalyzed Enantioselective Conjunctive Cross-Coupling of 9-BBN Borates" M. Chierchia, C. Law, and J. P. Morken, Angew. Chem. Int. Ed. 2017, 56, 11870.

MPC CML

 

 
 

92.

"A Boron Alkylidene-Alkene Cycloaddition Reaction: Application to the Synthesis of Aphanamal" X. Liu, T. M. Deaton, F. Haeffner, and J. P. Morken, Angew. Chem. Int. Ed. 2017, 56, 11485.

XL TMD

 

 
 

91.

"Enantioselective Conjunctive Cross-Coupling of Bis(alkenyl) Borates: A General Synthesis of Chiral Allylboron Reagents" E. K. Edelstein, S. Namirembe, and J. P. Morken, J. Am. Chem. Soc. 2017, 139, 5027.

EKE-SN

 

 

90.

"Pd-Catalyzed Conjunctive Cross-Coupling Between Grignard-Derived Boron "Ate" Complexes and C(sp2) Halides or Triflates: NaOTf as a Grignard Activator and Halide Scavenger" G. J. Lovinger, M. D. Aparece, and J. P. Morken, J. Am. Chem. Soc. 2017, 139, 3153.

GJL MDA

 

 

89.

"Modular, Catalytic Enantioselective Construction of Quaternary Carbon Stereocenters by Sequential Cross-Coupling Reactions" B. Potter, E. K. Edelstein, and J. P. Morken, Org. Lett. 2016, 18, 3286.

 

 

88.

"Nickel-Catalyzed Asymmetric Kumada Cross-Coupling of Symmetric Cyclic Sulfates" M. S. Eno, A. Lu, and J. P. Morken, J. Am. Chem. Soc. 2016, 138, 7824.

 

 

87.

"Carbohydrate-Catalyzed Enantioselective Alkene Diboration: Enhanced Reactivity of 1,2-Bonded Diboron Complexes" L. Fang, L. Yan, F. Haeffner, and J. P. Morken, J. Am. Chem. Soc. 2016, 138, 2508.

 

 

86.

"Catalytic Enantioselective Functionalization of Unactivated Terminal Alkenes" J. R. Coombs and J. P. Morken, Angew. Chem. Int. Ed. 2016, 55, 2636.

JRC

 

 

85.

"Catalytic conjunctive cross-coupling enabled by metal-induced metallate rearrangement" L. Zhang, G. J. Lovinger, E. K. Edelstein, A. A. Szymaniak, M. P. Chierchia and J. P. Morken, Science, 2016, 351, 70.

 

 

84.

"Hydroxyl-Directed Cross-Coupling: A Scalable Synthesis of Debromohamigeran E and Other Targets of Interest" T. P. Blaisdell and J. P. Morken, JACS, 2015, 137, 8712.

TPB

 

 

83.

"Enantioselective Hydroformylation of 1-Alkenes with Commercial Ph-BPE Ligand" Z. Yu, M. S. Eno, A. H. Annis, and J. P. Morken, Org Lett, 2015, 17, 3264.

ZY-MSE

 

 

82.

"Branched/Linear Selectivity in Palladium-Catalyzed Allyl-Allyl Cross-Couplings: The Role of Ligands" M. J. Ardolino and J. P. Morken, Tetrahedron (Special Issue for the Tsuji Tetrahedron Prize), 2015, 71, 6409.

MJA3

 

 

81.

"Synthesis of Vinyl Boronates from Aldehydes by a practical Boron-Wittig Reaction" J. R. Coombs, L. Zhang, and J. P. Morken, Org Lett. 2015, 17, 1708.

JRC-LZ2

 

   
 

80.

"Diastereoselective Ni-catalyzed 1,4-hydroboration of chiral dienols" R. J. Ely, Z. Yu, and J. P. Morken. Tetrahedron Lett (Wasserman Memorial Issue), 2015, 56, 3402.

RJE-ZY

 

79.

"Nonracemic Allylic Boronates through Enantiotopic-Group-Selective Cross-Coupling of Geminal (bis)Boronates and Vinyl Halides" B. Potter, A. A. Szymaniak, E. K. Edelstein, and J. P. Morken. J. Am. Chem. Soc. 2014, 136, 17918.

BP-AAS-EKE

 

 

78.

"Enantiomerically Enriched Tris(boronates): Readily Accessible Conjunctive Reagents for Asymmetric Synthesis" J. R. Coombs, L. Zhang, and J. P. Morken. J. Am. Chem. Soc. 2014, 136, 16140.

JRC-LZ

 

 

77.

"Enantioselective Carbocyle Formation through Intramolecular Pd-Catalyzed Allyl-Aryl Cross-Coupling" C. H. Schuster, J. R. Coombs, Z. A. Kasun, and J. P. Morken Org. Lett. 2014, 16, 4420.

CHS-JRC-AK

 

 

76.

"Simple Access to Elusive α-Boryl Carbanions and Their Alkylation: An Umpolung Construction for Organic Synthesis" K. Hong, X. Liu, and J. P. Morken J. Am. Chem. Soc. 2014, 136, 10581.

KH-XL

 

 

75.

"Synthesis of (+)-Discodermolide by Catalytic Stereoselective Borylation Reactions " Z. Yu, R. J. Ely, and J. P. Morken Angew. Chemie. Int. Ed. 2014, 53, 9632.

ZY-RE

 

 

74.

"Catalytic Bismetallative Multicomponent Coupling Reactions: Scope, Applications, and Mechanisms" H. Y. Cho, and J. P. Morken Chem. Soc. Rev. 2014, 43, 4368.

HYC

 

 

73.

"Hydroxyl-Directed Stereoselective Diboration of Alkenes" T. P. Blaisdell, T. C. Caya, L. Zhang, A. Sanz-Marco, and J. P. Morken J. Am. Chem. Soc. 2014, 136, 9264.

TPB-TCC-ASM

 

 

72.

"Congested C–C Bonds by Pd-Catalyzed Enantioselective Allyl–Allyl Cross-Coupling, a Mechanism-Guided Solution" M. J. Ardolino and J. P. Morken J. Am. Chem. Soc. 2014, 136, 7092.

MJA2

 

 

71.

"A Catalytic Enantiotopic-Group-Selective Suzuki Reaction for the Construction of Chiral Organoboronates" C. Sun, B. Potter and J. P. Morken J. Am. Chem. Soc. 2014, 136, 6534.

CS-BP

 

 

70.

"Catalytic Stereospecific Allyl–Allyl Cross-Coupling of Internal Allyl Electrophiles with AllylB(pin)" H. Le, A. Batten and J. P. Morken Org. Lett. 2014, 16, 2096.

HL-BP

 

 

 

69.

"Asymmetric Synthesis from Terminal Alkenes by Cascades of Diboration and Cross-Coupling" S. N. Mlynarski, C. H. Schuster and J. P. Morken Nature. 2014, 505, 386.

SNM-CHS

 

 

 

68.

"Stereocontrol in Palladium-Catalyzed Propargylic Substitutions: Kinetic Resolution to give Enantioenriched 1,5-Enynes and Propargylic Acetates" M. J. Ardolino, M. S. Eno and J. P. Morken Adv. Synth. Catal. 2013, 355, 3413.

MJA-MSE

 

67.

"Scope and Mechanism of the Pt-Catalyzed Enantioselective Diboration of Monosubstituted Alkenes" J. R. Coombs, F. Haeffner, L. T. Kliman and J. P. Morken J. Am. Chem. Soc. 2013, 135, 11222.

JRC-LTK

 

66.

"Catalytic Enantioselective One-pot Aminoborylation of Aldehydes: A Strategy for Construction of Nonracemic alpha-Amino Boronates" K. Hong and J. P. Morken J. Am. Chem. Soc. 2013, 135, 9252.

KH

 

65.

"Catalytic Enantioselective Allyl-Allyl Cross-Coupling with a Borylated Allylboronate" H. Le, R. E. Kyne, L. A. Brozek and J. P. Morken Org. Lett. 2013, 15, 1432.

HL-REK-LAB

 

 

 

64.

"A Catalytic Enantioselective Tandem Allylation Strategy for Rapid Terpene Construction: Application to the Synthesis of Pumilaside Aglycon" G. E. Ferris, K. Hong, I. A. Roundtree and J. P. Morken J. Am. Chem. Soc. 2013, 135, 2501.

GEF-KH-IAE

 

63.

"Direct Stereospecific Amination of Alkyl and Aryl Pinacol Boronates" S. N. Mlynarski, A. S. Karns and J. P. Morken J. Am. Chem. Soc. 2012, 134, 16449.

SNM-ASK

 

62.

 

"Construction of 1,5-Enynes by Stereospecific Pd-Catalyzed Allyl-Propargyl Cross-Couplings" M. J. Ardolino and J. P. Morken J. Am. Chem. Soc. 2012, 134, 8770.

MJA2

 

61

"Ni- and Pd-Catalyzed Synthesis of Substituted and Functionalized Allylic Boronates" P. Zhang, I. A. Roundtree and J. P. Morken Org. Lett. 2012, 14, 1416.

PZ-IAR

 

60.

"Catalytiic Enantioselective 1,2-Diboration of 1,3-Dienes: Versatile Reagents for Stereoselective Allylation" L. T. Kliman, S. N. Mlynarski, G. E. Ferris and J. P. Morken Angew. Chem. Int. Ed. 2012, 51, 521.

LTK-SNM-GEF

 

59.

"Diastereocontrol in Asymmetric Allyl-Allyl Cross-Coupling: Stereocontrolled Reaction of Prochiral Allylboronates with Prochiral Allyl Chlorides" L. A. Brozek, M. J. Ardolino and J. P. Morken J. Am. Chem. Soc. 2011, 133, 16778.

LAB-MJA

 

58.

"Catalytic Enantioselective Diboration of Cyclic Dienes: A Modified Ligand with General Utility" K. Hong and J. P. Morken J. Org. Chem. 2011, 76, 9102.

KH

 

57.

"Stereoselective Borylative Ketone-Diene Coupling" H. Y. Cho, Z. Yu and J. P. Morken Org. Lett. 2011,13, 5267.

HYC-ZY

 

56.

"Stereoselective Nickel-Catalyzed 1,4-Hydroboration of 1,3-Dienes" R. J. Ely and J. P. Morken Org. Synth. 2011, 88, 342.

RJE



55.

"Modular Monodentate Oxaphospholane Ligands: Utility in Highly Efficient and Enantioselective 1,4-Diboration of 1,3-Dienes" C. H. Schuster and J. P. Morken Angew. Chem. Int. Ed. 2011, 50, 7906.

CHS


54.

"Enantioselective Construction of All-Carbon Quaternary Centers by Branch-Selective Pd-Catalyzed Allyl-Allyl Cross-Coupling" P. Zhang, H. Le, R. E. Kyne and J. P. Morken J. Am. Chem. Soc. 2011, 133, 9716.

PZ-HL-REK



53.

"A Boron-Based Synthesis of the Natural Product (+)-trans-Dihydrolycoricidine" S. L. Poe and J. P. Morken Angew. Chem. Int. Ed. 2011, 50, 4189.

SLP



52.

"Catalytic Enantioselective Conjugate Allylation of Unsaturated Methylidene Ketones" L. A. Brozek, J. D. Sieber and J. P. Morken Org. Lett. 2011, 13, 995.

LAB-JDS



51.

"Enantioselective Synthesis of (-)-Sclerophytin A by a Stereoconvergent Expoxide Hydrolysis" B. Wang, A. P. Ramirez, J. J. Slade and J. P. Morken J. Am. Chem. Soc. 2010, 132, 16380.

BW-APR-JJS

50.

"Ni(0)-Catalyzed 1,4-Selective Diboration of Conjugated Dienes" R. J. Ely and J. P. Morken Org. Lett. 2010, 12, 4348.

RJE2


49.

"Allylation of Nitrosobenzene with Pinacol Allylboronates. A Regioselective Complement to Peroxide Oxidation" R. E. Kyne, M. C. Ryan, L. T. Kliman and J. P. Morken Org. Lett. 2010, 12, 3796.

REK-MCR-LTK

48.

"Pd-Catalyzed Carbonylative Conjugate Addition of Dialkylzinc Reagents to Unsaturated Carbonyls" D. W. Custar, H. Le and J. P. Morken Org. Lett. 2010, 12, 3760.

DWC-HL

47.

"Pd-Catalyzed Enantioselective Allyl-Allyl Cross-Coupling" P. Zhang, L. A. Brozek and J. P. Morken J. Am. Chem. Soc. 2010, 132, 10686.

PZ-LAB

46.

"Ni-Catalyzed Borylative Diene-Aldehyde Coupling: The Remarkable Effect of P(SiMe3)3" H. Y. Cho and J. P. Morken J. Am. Chem. Soc. 2010, 132, 7576.

HYC2

45.

"Regio- and Stereoselective Ni-Catalyzed 1,4-Hydroboration of 1,3-Dienes: Access to Stereodefined (Z)-Allylboron Reagents and Derived Allylic Alcohols" R. J. Ely and J. P. Morken J. Am. Chem. Soc. 2010, 132, 2534.

RJE3

44.

"Pt-Catalyzed Enantioselective Diboration of Terminal Alkenes with B2(pin)2" L. T. Kliman, S. N. Mlynarski and J. P. Morken J. Am. Chem. Soc. 2009, 131, 13210.

LTK-SNM

43.

"Catalytic Enantioselective Allylation of Dienals through the Intermediacy of Unsaturated pi-Allyl Complexes" P. Zhang and J. P. Morken J. Am. Chem. Soc. 2009, 131, 12550.

PZ

42.

"Asymmetric 1,4-Dihydroxylation of 1,3-Dienes by Catalytic Enantioselective Diboration" H. E. Burks, L. T. Kliman and J. P. Morken J. Am. Chem. Soc. 2009, 131, 9134.

HEB-LTK

41.

"Diastereoselective Construction of Functionalized Homoallylic Alcohols by Ni-Catalyzed Diboron-Promoted Coupling of Dienes and Aldehydes" H. Y. Cho and J. P. Morken J. Am. Chem. Soc. 2008, 130, 16140.

HYC3

40.

“Asymmetric Ni-Catalyzed Conjugate Allylation of Activated Enones” J. D. Sieber and J. P. Morken J. Am. Chem. Soc. 2008, 130, 4978.

JDS


39.

“Catalytic Enantioselective Diboration, Disilation and Silaboration: New Opportunities for Asymmetric Synthesis” H. E. Burks and J. P. Morken Chem. Commun. 2007, 4717.

HEB



38.

“Development, Mechanism, and Scope of the Palladium-Catalyzed Enantioselective Allene Diboration” H. E. Burks, S. Liu and J. P. Morken J. Am. Chem. Soc. 2007, 129, 8766.

HEB-SL


37.

“Catalytic Conjugate Addition of Allyl Groups to Styryl-Activated Enones” J. D. Sieber, S. Liu and J. P. Morken J. Am. Chem. Soc. 2007, 129, 2214.

JDS-SL


36.

“Ethylene Oligomerization Catalyzed by a Unique Phosphine-oxazoline Pd(II) Complex. Propagation and Chain Transfer Mechanisms” M. D. Doherty, S. Trudeau, P. S. White, J. P. Morken and M. S. Brookhart Organometallics 2007, 26, 1261.

MDD-ST-PSW

35.

“Catalytic, Diastereoselective Allylation of Oshima-Utimoto Products” R. A. Dueñes and J. P. Morken Synlett, 2007, 587.

RAD

34.

“Modular Asymmetric Synthesis of 1,2-Diols by Single-Pot Allene Diboration/Hydroboration/Cross-Coupling” N. F. Pelz and J. P. Morken, Organic Letters, 2006, 8, 4557.

NFP

33.

“StePHOX, A New Family of Optically Active, Tunable Phosphine-Oxazoline Ligands: Syntheses and Applications” S Trudeau and J. P. Morken, Tetrahedron 2006, 62, 11470.

ST


32.

“Rh-Catalyzed Enantioselective Hydrogenation of Vinyl Boronates for the Construction of Secondary Boronic Esters.” W. J. Moran and J. P. Morken, Organic Letters, 2006, 8, 2413.

WJM

31.

“Pd-Catalyzed Tandem Asymmetric Allene Diboration/α-Aminoallylation.” J. D. Sieber and James P. Morken J. Am .Chem. Soc. J. Am. Chem. Soc. 2006, 128, 74.

JDS2

30.

“Concatenated Catalytic Asymmetric Allene Diboration-Allylation-Functionalization” A. R. Woodward, H. E. Burks, L. M. Chan, J. P. Morken Organic Letters, 2005, 7, 5505.

ARW-HEB-LMC

29.

“Short and Efficient Total Synthesis of Fraxinellone Limonoids Using the Stereoselective Oshima-Utimoto Reaction.” S. Trudeau, J. P. Morken Organic Letters, 2005, 7, 5465.

ST2

28.

“Rh-Catalyzed Enantioselective Diboration of Simple Alkenes: Reaction Development and Substrate Scope” S. Trudeau, J. B. Morgan, M. Shrestha, J. P. Morken J. Org. Chem., 2005, 70, 9538.

ST-JBM-MS

27.

“Studies in the Synthesis of the Inostamycin Natural Products: A Reductive Aldol / Reductive Claisen Approach to the C10-C24 Ketone Fragment” N. O. Fuller and J. P. Morken Organic Letters, 2005, 7, 4867.

NOF

26.

“Asymmetric Synthesis of (-)-Dihydroxanthatin by the Stereoselective Oshima-Utimoto Reaction.” M. A. Evans and J. P. Morken, Organic Letters 2005, 7, 3371.

MAE

25.

“Stereoselective Synthesis of Furans by the Pd-Catalyzed Oshima-Utimoto Reaction” M. A. Evans and J. P. Morken Organic Letters 2005, 7, 3367.

MAE2

24.

“Direct Formation of Synthetically Useful Silyl-Protected Aldol Adducts via the Asymmetric Reductive Aldol Reaction” N. O. Fuller and J. P. Morken Synlett 2005, 1459.

NOF2

23.

“Regioselective Homologation of Bis(boronate) Intermediates Derived from Rhodium Catalyzed Diboration of Simple Alkenes.” D. M. Kalendra, R. A. Dueñes, and J. P. Morken Synlett 2005, 1749.

RAD-DMK

22.

“Palladium-Catalyzed Enantioselective Diboration of Prochiral Allenes.” N. F. Pelz, A. R. Woodward, H. E. Burks, J. D. Sieber and J. P. Morken. J. Am. Chem. Soc. 2004, 126, 16328.

NFP-ARW-HEB-JDS

21.

“Catalytic Enantioselective Hydrogenation of Vinyl Bis(boronates).” J. B. Morgan and J. P. Morken, J. Am. Chem. Soc. 2004, 126, 15338.

JBM

20.
“Investigation of the Rh-Catalyzed Asymmetric Reductive Aldol Reaction. Expanded Scope Based on Reaction Analysis.” A. E. Russell, N. O. Fuller, S. J. Taylor, P. Aurriset and J. P. Morken, Organic Letters, 2004, 6, 2309.
AER-NOF-SJT-PA

19.

“Platinum-Catalyzed Tandem Diboration/Intramolecular Allylboration: Diastereoselective Access to Cyclohexanes Bearing 1,3-Diols” E. Ballard and J. P. Morken, Synthesis 2004, 9, 1321.

CEB

18.

“Catalytic Asymmetric Carbohydroxylation of Alkenes by a Tandem Diboration/Suzuki Cross-Coupling/Oxidation Reaction.” Steven P. Miller, Jeremy B. Morgan, Felix J. Nepveux V and James P. Morken, Organic Letters, 2004, 6, 131.

SPM-JBM-FJV

17.

“Rhodium-Catalyzed Enantioselective Diboration of Simple Alkenes”, J. B. Morgan, S. P. Miller and J. P. Morken, J. Am. Chem. Soc. 2003, 125, 8702.

JBM-SPM

16.

“Platinum-Catalyzed Tandem Diboration/Asymmetric Allylboration: Access to Nonracemic Functionalized 1,3-Diols.”, Jeremy B. Morgan and James P. Morken, Organic Letters, 2003, 5, 2573.

JPM2

15.

“Enantioselective Total Synthesis of Borrelidin.” M. O. Duffey, A. LeTiran and J. P. Morken, J. Am. Chem. Soc. 2003, 125, 1458.

MOD-AL

14.

“Catalytic Diastereoselective Reductive Claisen Rearrangement.” S. P. Miller and J. P. Morken, Organic Letters 2002, 4, 2743.

SPM

13.

“Isotopically Chiral Probes for in situ High-Throughput Asymmetric Reaction Analysis.” M. A. Evans and J. P. Morken, J. Am. Chem. Soc. 2002, 124, 9020.

MAE3

12.

“Stereoselective Synthesis of Trans β-Lactams Through Iridium-Catalyzed Reductive Coupling of Imines and Acrylates.” J. A. Townes, M. Evans, J. Quefflec, S. J. Taylor and J. P. Morken Organic Letters, 2002, 4, 2537.



11.

“Discovery of a Novel Synthetic Phosphatase from a Bead-Bound Combinatorial Library.” S. Danek, J. Queffelec and J. P. Morken, Chem. Commun. 2002, 528.

SCD-JQ

10.
“500 μm Diameter Beads as Single Reactors to Screen Organometallic Catalysts: Discovery of a New Supported Catalyst for the Hydrosilylation of Ketones.” O. Lavastre and J. P. Morken, New Journal of Chemistry 2002, 26, 745-749.

9.

“Enantio- and Diastereoselective Reductive Aldol Reactions with Iridium-Pybox Catalysts”, C.-X. Zhao, M. O. Duffey, S. J. Taylor and J. P. Morken Organic Letters 2001, 3, 1829.

CXZ-MOD-SJT

8.

“Generation of E-Silylketene Acetals in a Rhodium-DuPhos Catalyzed Two-Step Reductive Aldol Reaction.” C.-X. Zhao , J. Bass and J. P. Morken Organic Letters 2001, 3, 2839.

CXZ-JB

7.

“Development of the First Catalytic Asymmetric Aldol-Tishchenko Reaction. Insight into the Catalyst Structure and Reaction Mechanism.” C. M. Mascarenhas, S. P. Miller and J. P. Morken Angew. Chem. Int. Ed. 2001, 40, 601.

CMM-SPM-PSW

6.

“Efficient Lewis Acid Catalyzed Intramolecular Cannizzaro Reaction.”, A. E. Russell, S. P. Miller, J. P. Morken J. Org. Chem. 2000, 65, 8381.

SER-SPM

5.

“Rhodium-Catalyzed Enantioselective Reductive Aldol Reaction.”, S. J. Taylor, M. O. Duffey and J. P. Morken J. Am. Chem. Soc. 2000, 122, 4528.

SJT-MOD


4.

“Catalytic Diastereoselective Reductive Aldol Reaction: Optimization of Interdependent Reaction Variables by Arrayed Catalyst Evaluation”, S. J. Taylor and J. P. Morken J. Am. Chem. Soc. 1999, 121, 12202.

pub4

3.

“Simple Metal-Alkoxides as Effective Catalysts for the Hetero Aldol-Tishchenko Reaction.” C. M. Mascarenhas, M. O. Duffey, S. Y. Liu and J. P. Morken Organic Letters 1999, 1, 1427.

CMM-MOD-SYL

2.

“Discovery of Novel Catalysts for Allylic Alkylation with a Visual Colorimetric Assay” O. Lavastre and J. P. Morken Angew. Chem. Int. Ed. 1999, 38, 3163.

pub2



1.

“Thermographic Selection of Effective Catalysts from an Encoded Polymer-Bound Library” S. J. Taylor and J. P. Morken. Science, 1998, 280, 267.

pub1