Department of Chemistry
Boston College

Gao Research Group

Synthetic Amino Acids
Membrane Active Peptides
Bacterial Targeting
Tumor Targeting

 

 

 

 

Publications
     
 

Publications at Boston College

  1. Anupam Bandyopadhyay, Samantha Cambray and Jianmin Gao*, “ Fast and selective labeling of N-terminal cysteines at neutral pH via thiazolidino boronate formation. ” Chem. Sci. 2016, (Accepted).
  1. Anupam Bandyopadhyay and Jianmin Gao*, “ Iminoboronate-based peptide cyclization that responds to pH, oxidation, and small molecule modulators. ” J. Am. Chem. Soc. 2016, 138, 2098-2101. PubMed. Access the recommendation on F1000Prime
  1. Breanna L. Zerfas, Yechaan Joo and Jianmin Gao*, “Gramicidin A mutants with antibiotic activity against both gram-positive and gram-negative bacteria, ” ChemMedChem 2016, (In press). PubMed
  1. Anupam Bandyopadhyay and Jianmin Gao*, “Iminoboronate Formation Leads to Fast and Reversible Conjugation Chemistry of α-Nucleophiles at Neutral pH, ” Chem. -Euro. J. 2015, 21, 14748-14752. PubMed
  1. Breanna L. Zerfas and Jianmin Gao*, “Recent Advances in Peptide Immunomodulators, ” Curr. Top. Med. Chem. 2015, 16, 187-205. PubMed
  1. Tao He, Anne Gershenson, Stephen J. Eyles, Yan-Jiun Lee, Wenshe R. Liu, Jiangyun Wang, Jianmin Gao, and Mary F. Roberts*, “Fluorinated aromatic amino acids distinguish cation-π interactions from membrane insertion, ” J. Biol. Chem. 2015, 290, 19334-19342. PubMed
  1. Anupam Bandyopadhyay, Kelly MaCarthy, Mike Kelly and Jianmin Gao*, “Targeting Bacteria via Iminoboronate Chemistry of Amine-Presenting Lipids, ” Nat. Commun. 2015, 6:6561 PubMed
  1. Azade Hosseini, Hong Zheng and Jianmin Gao*, “Understanding Lipid Recognition by Protein-Mimicking Cyclic Peptides, ” Tetrahedron 2014, 70, 7632-7638. PubMed
  1. Ya-Juan Wang*, Bamidele O. Tayo, Anupam Bandyopadhyay, Heming Wang, Tao Feng, Nora Franceschini, Hua Tang, Jianmin Gao, Yun Ju Sung, COGENT BP consortium, Robert C. Elston, Scott M. Williams, Richard S. Cooper , Ting-Wei Mu, Xiaofeng Zhu* “The Association of the Vanin-1 N131S Variant with Blood Pressure is Mediated by Endoplasmic-Reticulum-Associated Degradation and Loss of Function, ” PLOS Gent. 2014, 10, e1004641. PubMed.
  1. Anupam Bandyopadhyay and Jianmin Gao*, “Cancer-targeting peptides, ” Book Chapter 5 in Advances in the discovery and development of peptide therapeutics (Eds.: Kruger G. and Albericio F.); Future Science Ltd., 2014. Link.
  1. Fang Wang, Luoheng Qin, Patrick Wong and Jianmin Gao*, “Effects of Lysine Methylation on Gramicidin A Folding in Lipid Membranes, ” Biopolymers: Pept. Sci. 2013, 100, 656-61. PubMed
  1. Lauren K. Regula, Richard Harris, Fang Wang, Jayne F. Koellhoffer, Chelsea D. Higgins, Kartik Chandran, Jianmin Gao, Mark E. Girvin, and Jonathan R. Lai*, “Conformation and Lipid-Binding Properties of Peptides Corresponding to the Ebolavirus GP2 Membrane-Proximal External Region,” Biochem., 2013, 52, 3393-404. PubMed
  1. Jianmin Gao* and Hong Zheng, “Recent Developments of Peptide-Based Markers of Membrane Lipids,” Future Med. Chem. 2013, 5, 947-59. PubMed
  1. Christopher Pace and Jianmin Gao*, “Exploring and Exploiting Polar—π Interactions with Fluorinated Aromatic Amino Acids,” Acc. Chem. Res. 2013, 46, 907-15. PubMed

  1. Christopher Pace, Diane Kim and Jianmin Gao*, “Experimental Evaluation of CH—π Interactions in a Protein Core,” Chem. Euro. J. 2012, 18, 5832-6. PubMed

  1. Yue Zhao and Jianmin Gao*, “Split Ligand for Lanthanide Binding: Facile Evaluation of Dimerizing Proteins,” Chem. Comm. 2012, 48, 2997-9. PubMed

  1. Luoheng Qin, Christopher Sheridan and Jianmin Gao*, “Synthesis of Tetrafluorinated Aromatic Amino Acids with Distinct Signatures in 19F-NMR,” Org. Lett. 2012, 14, 528-31. PubMed


 

  1. Fang Wang, Luoheng Qin, Christopher J. Pace, Patrick Wong, Ryan Malonis and Jianmin Gao*, “Solubilized Gramicidin A as Potential Systemic Antibiotics,” ChemBioChem 2012, 13, 51-5. PubMed

  1. Christopher Pace, Hong Zheng, Ruben Mylvaganam, Diane Kim and Jianmin Gao*, “Stacked Fluoroaromatics as Supramolecular Synthons for Programming Protein Dimerization Specificity,” Angew. Chem., Int. Ed. 2012, 51, 103-7. PubMed

  1. Hong Zheng, Fang Wang, Qin Wang and Jianmin Gao*, “Cofactor-Free Detection of Phosphatidylserine with Cyclic Peptides Mimicking Lactadherin,” J. Am. Chem. Soc. 2011, 133, 15280-3. PubMed

  1. Christopher Pace, Qiongying Huang, Fang Wang, Kanwal S. Palla, Amelia A. Fuller and Jianmin Gao*, “A FlAsH-tetracysteine Assay for Quantifying the Association and Orientation of Transmembrane a-Helices,” ChemBioChem 2011, 12, 1018-22. PubMed

  1. Fang Wang, Luoheng Qin, Patrick Wong and Jianmin Gao*, “Facile Synthesis of Tetrafluorotyrosine and Its Application in pH Triggered Membrane Lysis,” Org. Lett. 2011, 13, 236-9. This paper is highlighted in the recent virtual issue of ACS on peptide chemistry.  See the intro to the virtual issue by Professor Lubell, Org. Lett. 2012, 14, 4297-302. PubMed

  1. Hong Zheng and Jianmin Gao*, “Highly Specific Heterodimerization Mediated by Quadrupole Interactions,” Angew. Chem., Int. Ed. 2010, 49, 8635-9. This article was rated as a Very Important Paper. See highlight by Kros et al. “Introducing Quadrupole Interactions into the Peptide Design Toolkit,” Angew. Chem., Int. Ed. 2010, 49, 8570-2. PubMed

  1. Luoheng Qin, Julian Vastl and Jianmin Gao*, “Highly Sensitive Amyloid Detection Enabled by Thioflavin T Dimers,” Mol. Biosyst. 2010, 6, 1791-5.  PubMed

  1. Hong Zheng, Kristofer Comeforo and Jianmin Gao*, “Expanding the Fluorous Arsenal: Tetrafluorinated Phenylalanines for Protein Design,” J. Am. Chem. Soc. 2009, 131, 18-9. PubMed

Publications from Scripps

  1. Jianmin Gao, Daryl A. Bosco, Evan T. Powers, and Jeffery W. Kelly*, “Localized Thermodynamic Coupling between Hydrogen Bonding and Microenvironment Polarity Significantly Stabilizes Proteins,” Nat. Struct. Mol. Biol. 2009, 16, 684-90.
  1. Michelle R. Bunagan, Jianmin Gao, Jeffery W. Kelly*, and Feng Gai* “Probing the Folding Transition State Structure of the Villin Headpiece Subdomain via Sidechain and Backbone Mutagenesis,” J. Am. Chem. Soc.   2009, 131, 7470-6.
  1. Marcus Jager, Songpon Deechongkit, Edward K. Koepf, Houbi Nguyen, Jianmin Gao, Evan T. Powers, Martin Gruebele, and Jeffery W. Kelly*, “Understanding the Mechanism of b-sheet Folding from a Chemical and Biological Perspective,” Biopolymers 2008, 90, 751-8.
  1. Jianmin Gao and Jeffery W. Kelly*, “Towards Quantification of Protein Backbone-Backbone Hydrogen Bonding Energies: An Energetic Analysis of an Amide-to-Ester Mutation in an a-Helix within a Protein,” Protein Sci. 2008, 1096-101.
  1. Yanwen Fu, Jianmin Gao, Jan Bieschke, Maria, A. Dendle, and Jeffery W. Kelly*, “Amide-to-E-Olefin versus Amide-to-Ester Backbone H-Bond Perturbations: Evaluating the Repulsive Lone Pair-Lone Pair interaction for Extracting H-Bond Energies,” J. Am. Chem. Soc.   2006, 128, 15948-9.
  1. Yan Zhang, Youngjun Kim, Nicolas Genoud, Jianmin Gao, Jeffery W. Kelly, Samuel L. Pfaff, Gordon N. Gill, Jack E. Dixon, and Joseph P. Noel* “Determinants for Dephosphorylation of the RNA Polymerase II C-terminal Domain by Scp1,” Mol. Cell. 2006, 24, 759-70.

Publications from Stanford

  1. Sarah K. Jarchow-Choy, Andrew T. Krueger, Haibo Liu, Jianmin Gao and Eric T. Kool*, “Fluorescent xDNA Nucleotides as Efficient Substrates for a Template-independent Polymerase,” Nucleic Acids Res. 2011, 39, 1586-94.
  1. Haige Lu, Andrew T. Kruger, Jianmin Gao, Haibo Liu and Eric T. Kool*, “Toward a Designed Genetic System with Biochemical Function: Polymerase Synthesis of Single and Multiple Size-Expanded DNA Base Pairs,” Org. Biomol. Chem. 2010, 8, 2704-10.
  1. James C. Delaney, Jianmin Gao, Haibo Liu, Nidhi Shrivastav, John M. Essigmann* and Eric T. Kool*, “Efficient Replication Bypass of Size-expanded DNA Base Pairs in Bacterial Cells,” Angew. Chem., Int. Ed. 2009, 48, 4254-7.
  1. James N. Wilson, Jianmin Gao, and Eric T. Kool*, “Oligodeoxyfluorosides: Strong Sequence Dependence of Fluorescence Emission,” Tetrahedron 2007, 63, 3427-33.
  1. Stephen R. Lynch, Haibo Liu, Jianmin Gao, and Eric T. Kool*, “Toward a Designed, Functioning Genetic System With Expanded-size Base Pairs: Solution Structure of the 8-Base xDNA Double Helix,” J. Am. Chem. Soc. 2006, 128, 14704-11 (This work is featured in a Research Highlight in Nature, 2006, 444, 5 and highlighted in the News and Views  in Nature, 2006, 444, 554-5).
  1. “Assembly of the Complete Eight-Base Artificial Genetic Helix, xDNA, and Its Interaction with the Natural Genetic System,” Angew. Chem., Int. Ed. 2005, 44, 3118-22. (†co first author. This paper is featured in Chemical and Engineering News, 2005, 83, 23.)
  1. Haibo Liu, Jianmin Gao, and Eric T. Kool*, “Helix-forming Properties of Size-expanded DNA (xDNA), an Alternative Four-base Genetic Form,” J. Am. Chem. Soc. 2005, 127, 1396-402.
  1. Haibo Liu, Jianmin Gao, and Eric T. Kool*, “Size-expanded Analogues of dG and dC.  Synthesis and Pairing Properties in DNA,” J. Org. Chem. 2005, 70, 639-47.
  1. Jianmin Gao, Soichiro Watanabe, and Eric T. Kool*, “Modified DNA Analogues That Sense Light Exposure with Color Changes,” J. Am. Chem. Soc. 2004, 126, 12748-9. (This work is featured in a Research Highlight in Nature Methods 2004, 1, 100-1.)
  1. Jianmin Gao, Haibo Liu, and Eric T. Kool*, “Expanded-Size Bases in Naturally Sized DNA: Evaluation of Steric Effects in Watson-Crick Pairing,” J. Am. Chem. Soc. 2004, 126, 12748-9.
  1. Haibo Liu, Jianmin Gao, Y.David Saito, Lystranne Maynard, Eric T. Kool*, “Toward a New Genetic System with Expanded Dimensions: Size-expanded Analogues of Deoxyadenosine and Thymidine,” J. Am. Chem. Soc. 2004, 126, 1102-9.
  1. Haibo Liu, Jianmin Gao, Stephen Lynch, Y.David Saito, Lystranne Maynard, Eric T. Kool*, “A Four-base-pair Genetic Helix with Expanded Size,” Science 2003, 302, 868-71. (This paper is reported in Chemical and Engineering News 2003, 81, 3, highlighted in Angew. Chem., Int. Ed. 2004, 43, 1625-6, and featured in ChemBioChem 2004, 5, 765-7.)
  1. Jianmin Gao, Christoph Strassler, Deborah Tahmassebi, and Eric T. Kool*, “Libraries of Composite Polyfluors Built from Fluorescent Deoxyribosides,” J. Am. Chem. Soc., 2002, 124, 11590-1.
 
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