marc snapper laboratory URLsPublicationsGroup InfoResearchMarc SnapperHome
 
curriculum vitae
 
publications
 
teaching
 

Publications

1. "Total Synthesis of (-)-Ilimaquinone" Bruner, S.D.; Radeke, H.S.; Tallarico, J.A.; Snapper, M.L. J. Org. Chem.1995, 60, 1114. 

2. "Selective Ring-Opening Cross-Metathesis. Short Syntheses of Multifidene and Viridiene"Randall, M.L.; Tallarico, J.A.; Snapper, M.L. J. Am. Chem. Soc. 1995, 117, 9610.

3. "Discovery of Chiral Catalysts Through Ligand Diversity: Ti-Catalyzed Enantioselective Addition of TMSCN to Meso Epoxides" Cole, B.M.; Shimizu, K.D.; Krueger, C.A.; Harrity, J.P.A.; Snapper, M.L.; Hoveyda, A.H. Angew. Chem., Int. Ed. Engl. 1996, 35, 1668.

4. "Intramolecular Cycloadditions Between Cyclobutadiene and Alkenes" Tallarico, J.A.; Randall, M.L.; Snapper, M.L. J. Am. Chem. Soc. 1996, 118, 9196.

5. "Regio- and Stereoselective Ring-Opening Cross-Metathesis. Rapid Entry into Functionalized Bicyclo[6.3.0] Ring Systems" Snapper, M.L.; Tallarico, J.A.; Randall, M.L. J. Am. Chem. Soc. 1997, 119, 1478.

6. "New Tools for Studying Vesicular-Mediated Protein Trafficking:  Synthesis and Evaluation of Ilimaquinone Analogs in a Non-Radioisotope-Based Anti-Secretory Assay" Radeke, H.S.; Digits, C.A.; Bruner, S.D.; Snapper, M.L. J. Org. Chem.1997, 62, 2823.

7. "Ring Opening Metathesis. A Ruthenium Catalyst Caught in the Act" Tallarico, J.A.; Bonitatebus, Jr., P.J.; Snapper, M.L. J. Am. Chem. Soc 1997, 119, 7157.

8. "Search for Chiral Catalysts Through Ligand Diversity: Substrate Specific Catalysts and High-Throughput Ligand Screening on Solid Phase" Shimizu, K.D.; Cole, B.M.; Krueger, C.A.; Kuntz, K.W.; Snapper, M.L.; Hoveyda, A.H. Angew. Chem., Int. Ed. Engl. 1997, 36, 1704.

9. "Selectivity in Ring-Opening Cross-Metatheses" Tallarico, J.A.; Randall, M.L.; Snapper, M.L. Tetrahedron 1997, 53, 16511.

10. "Selective Olefin Cross-Metatheses. New Tools for the Organic Chemist" Randall, M.L.; Snapper, M.L. J. Mol. Cat.1998, 133, 29.

11. "Photoaffinity Study of the Cellular Interactions of Ilimaquinone" Radeke, H.S.; Snapper, M.L. Bioorg. Med. Chem.1998, 6, 1227.

12. "High-Throughput Strategies for the Discovery of Catalysts" Shimizu, K.D.; Snapper, M.L.; Hoveyda, A.H. Chem. Eur. J. 1998, 4, 1885.

13. "Applications of Olefin Metathesis in Organic Synthesis" Randall, M.L.; Snapper, M.L. Strem Chemiker. 1998, 17, 1.

14. "Intramolecular Cycloadditions Between Cyclobutadiene and Dienes" Limanto, J.; Snapper, M.L. J. Org. Chem. 1998, 63, 6440.

15. "New Reactivity From (PCy3)2Cl2Ru=CHPh: A Mild Catalyst for Kharasch Additions" Tallarico, J. A.; Malnick, L.M.; Snapper, M. L. J. Org. Chem. 1999, 64, 344.

16. "Ti-Catalyzed Enantioselective Addition of Cyanide to Imines. A Practical Synthesis of Optically Pure a-Amino Acids" Krueger, C.A.; Kuntz; K.W.; Dzierba, C.D.; Wirschun, W.G.; Gleason, J.D.; Snapper, M.L.; Hoveyda, A.H. J. Am. Chem. Soc. 1999, 121, 4284.

17. "Interactions of (-)-Ilimaquinone with Methylation Enzymes: Implications for Vesicular-Mediated Secretion" Radeke, H.S.; Digits, C.A.; Casaubon, R. L.; Snapper, M.L. Chem. Bio. 1999, 6, 639.

18. "[2+2]Photocycloaddition/Thermal Retro-cycloaddition. A New Entry into Functionalized 5-8-5 Ring Systems" Randall, M.L.; Lo, P.; Bonitatebus, Jr., P.J.; Snapper, M.L. J. Am. Chem. Soc.1999, 121, 4534.

19. "Combinatorial Approaches to Chiral Catalyst Discovery" Snapper, M.L.; Hoveyda, A.H. in Combinatorial Chemistry: A Practical Approach, Fenniri, H. (Ed), in press.

20. "Formation of Carbon-Carbon Bonds Using Iron Tricarbonyl-(h4-cyclo-buta-dienyl)-Stabilized Carbonium Ions" Porter, J. R.; Snapper, M.L. Synthesis 1999, 1407.

21. "Combinatorial Catalyst Discovery" Kuntz, K.W.; Snapper, M.L.; Hoveyda, A.H. Cur. Op. Chem. Biol. 1999, 3, 311.

22. "Ti-Catalyzed Regio- and Enantioselective Synthesis of Unsaturated a-Amino Nitriles, Amides and Acids. Catalyst Identification through Screening of Parallel Libraries" Porter, J.R.,; Wirschun, W.G.; Kuntz, K.W.; Snapper, M.L.; Hoveyda, A.H. J. Am. Chem. Soc. 2000, 122, 2657.

23. "Sequential Intramolecular Cyclobudadiene Cycloaddition, Ring Opening Metathesis, and Cope Rearrangement: Total Syntheses of (+)- and (-)-Asteriscanolide" Limanto, J.; Snapper, M.L. J. Am. Chem. Soc. 2000, 122, 8071.

24. "Ring Opening Metathesis Approach to the Isoprostanes" Schrader, T. O.; Snapper, M. L. Tetrahedron Lett. 2000, 41, 9685.

25. "Enantioselective Synthesis of Arylamines Through Zr-Catalyzed Addition of Dialkylzincs to Imines. Reaction Development by Screening of Parallel Libraries" Porter, J. R.; Traverse, J. F.; Hoveyda, A. H.; Snapper, M. L. J. Am. Chem. Soc. 2001, 123, 984.

26. "S-Adenosylmethionine Reverses Ilimaquinone's Vesiculation of the Golgi Apparatus A Fluorescence Study on the Cellular Interactions of Ilimaquinone" Casaubon, R. L.; Snapper, M. L. Bioorg. Med. Chem. Lett. 2001, 11, 133.

27. "New Entry into Fuctionalized [5.3.0] Ring Systems." Deak, H. D; Stokes, S. S.; Snapper, M. L. J. Am. Chem. Soc. 2001, 123, 5152.

28. "Intramolecular [2 + 2]- Photocycloaddition/Thermal Fragmentation Approach toward 5-8-5 Ring Systems" Lo, P; Snapper, M. L. Org. Lett. 2001, 3, 2819.

29. "Three-Component Catalytic Asymmetric Synthesis of Aliphatic Amines" Porter, J. R.; Traverse, J. F.; Hoveyda, A. H.; Snapper, M. L. J. Am. Chem. Soc. 2001, 123, 10409.

30. "Stereodivergent Synthesis of All 15-F2 Isoprostanes" Schrader, T. O.; Snapper, M. L. J. Am. Chem. Soc. 2002, 124, 10998.

31. "Total Synthesis of (+)- and (-)-Cacospongionolide B: New Insight into Structural Requirements for Phospholipase A2 Inhibition" Cheung, A. K.; Snapper, M. L. J. Am. Chem. Soc. 2002, 124, 11584.

32. "High-throughput methods for the development of new catalytic asymmetric reactions" Traverse, J. F.; Snapper, M. L. Drug Discovery Today 2002, 7, 1002.

33. "New Tandem Catalysis: Preparation of Cyclic Enol Ethers through a Ruthenium-Catalyzed Ring-Closing Metathesis-Olefin Isomerization Sequence" Sutton, A. E.; Seigal, B. A.; Finnegan, D. F.; Snapper, M. L. J. Am. Chem. Soc. 2002, 124, 13390.

34. "Intramolecular Cycloadditions of Cyclobutadienes with Olefins" Limanto, J.; Tallarico, J. A.; Porter, J. R.; Khuong, K.; Houk, K. H.; Snapper, M. L. J. Am. Chem. Soc. 2002, 124, 14748.

35. "Multiple Component Reactions: An Efficient Nickel-Catalyzed Reformatskii-Type Reaction and Its Application in the Parallel Synthesis of ? -Amino Carbonyl Libraries." Adrian, James C., Jr.; Snapper, Marc L.. J. Org. Chem. 2003, 68, 2143.

36. "Efficient and Practical Ag-Catalyzed Cycloadditions between Arylimines and the Danishefsky Diene." Josephsohn, Nathan S.; Snapper, Marc L.; Hoveyda, Amir H. J. Am. Chem. Soc. 2003, 125, 4018.

37. "A Stereoselective Enyne Cross Metathesis." Lee, Hee-Yoon; Kim, Byung Gyu; Snapper, Marc L.. Org. Lett. 2003, 5, 1855.

38. "Total Synthesis of Anti-HIV Agent Chloropeptin I." Deng, Hongbo; Jung, Jae-Kyung; Liu, Tao; Kuntz, Kevin W.; Snapper, Marc L.; Hoveyda, Amir H. J. Am. Chem. Soc. 2003, 125, 9032.

39. "Enantioselective Synthesis of Propargylamines through Zr-Catalyzed Addition of Mixed Alkynylzinc Reagents to Arylimines." Traverse, John F.; Hoveyda, Amir H.; Snapper, Marc L.. Org. Lett. 2003, 5, 3273.

40. "Three-component enantioselective synthesis of propargylamines through Zr-catalyzed additions of alkylzinc reagents to alkynylimines." Akullian, Laura C.; Snapper, Marc L.; Hoveyda, Amir H. Angew. Chem. Int. Ed. 2003, 42, 4244.

41. "Ring-Opening Metathesis/Oxy-Cope Rearrangement: A New Strategy for the Synthesis of Bicyclic Medium Ring-Containing Compounds." White, Brian H.; Snapper, Marc L.. J. Am. Chem. Soc. 2003, 125, 14901.

42. "Intramolecular Cycloadditions of Cyclobutadiene with Dienes: Experimental and Computational Studies of the Competing (2 + 2) and (4 + 2) Modes of Reaction." Limanto, John; Khuong, Kelli S.; Houk, K. N.; Snapper, Marc L.. J. Am. Chem. Soc. 2003, 125, 16310.

43. "Total syntheses of (+)- and (-)-cacospongionolide B, cacospongionolide E, and related analogues. Preliminary study of structural features required for phospholipase A(2) inhibition" Cheung Atwood K.; Murelli Ryan P.; Snapper, Marc L.. J. Org. Chem. 2004, 69, 5712.

44. "(PCy3)(2)Cl2Ru=CHPh Catalyzed Kharasch additions. Application in a formal olefin carbonylation " Lee BT, Schrader TO, Martin-Matute B, Kauffman CR, Zhang P,; Snapper, Marc L.. Tetrahedron 2004, 60, 7391.

45. "Ag-catalyzed asymmetric Mannich reactions of enol ethers with aryl, alkyl, alkenyl, and alkynyl imines " Josephson, NS; Snapper, Marc L.; Hoveyda, Amir H.;. J. Am. Chem. Soc. 2004, 126, 3734.

46. "Intramolecular [2+2] Photocycloaddition/thermal fragmentation: Formally "allowed" and "forbidden" pathways toward 5-8-5 ring systems" Bader, Scott J.; Snapper, Marc L.. J. Am. Chem. Soc. 2005, 127, 1201.

47. "Asymmetric synthesis of acyclic amines through Zr- and Hf-catalyzed enantioselective alkylzinc reagents to Imines"Akulian, Laura C.; Porter, James R.; Traverse, John F.; Snapper, Marc L.; Hoveyda, Amir H. Advanced Synthesis And Catalysis 2005, 347, 417.

48. "Isocomplestatin: Total Synthesis and Stereochemical Revision " Shinohara, Toshio; Deng, Hongbo; Snapper, Marc L.; Hoveyda, Amir H. J. Am. Chem. Soc. 2005, 127, 7334.

49. "Practical and highly enantioselective synthesis of beta-alkynyl-beta-amino esters through Ag-catalyzed asymmetric Mannich reactions of silylketene acetals and alkynyl imines" Josephson, Nathan S.; Carswell, Emma L.; Snapper, Marc L.; Hoveyda, Amir H. Org. Lett. 2005, 7, 2711.

50. "Proline-Based N-Oxides as Readily Available and Modular Chiral Catalysts. Enantioselective Reactions of Allyltrichlorosilane with Aldehydes" Traverse, John F.; Zhao, Yu; Hoveyda, Amir H.; Snapper, Marc L. Org. Lett. 2005, 7, 3151.

51. "Intramolecular [2+2+1] Cycloadditions with (Cyclobutadiene)tricarbonyliron" Seigal, Benjamin A.; An, Mi H.; Snapper, Marc L. Angew. Chem. Int. Ed. 2005, 44, 4929.

52. "Al-Catalyzed Enantioselective Alkylation of -Ketoesters by Dialkylzinc Reagents. Enhancement of Enantioselectivity and Reactivity by an Achiral Lewis Base Additive" Wieland, Laura C.; Deng, Hongbo; Snapper, Marc L.; Hoveyda, Amir H. J. Am. Chem. Soc. 2005, 127, 15453.

53. "Tandem Catalysis: Generating Multiple Contiguous Carbon-Carbon Bonds through a Ruthenium-Catalyzed Ring-Closing/Kharasch Addition" Seigal, Benjamin A.; Fajardo, Cristina; Snapper, Marc L. J. Am. Chem. Soc. 2005, 127, 16329.

54. "Lewis acid-mediated generation of bicyclo[5.3.0]decanes and bicyclo[4.3.0]nonanes" Deak, Holly, L.; Williams, Michael J.; Snapper, Marc L. Org. Lett 2005, 7, 5785.

55. "Preparation of alkenyl cyclopropanes through a ruthenium-catalyzed tandem enyne metathesis-cyclopropanation sequence" Kim, Byung G.; Snapper, Marc L. J. Am. Chem. Soc. 2006, 128, 52.

56. "Synthesis of isoprostanyl phosphatidylcholine and isoprostanyl phosphatidylethanolamine" Shizuka, Manami; Schrader, Thomas O.; Snapper, Marc L. J. Org. Chem. 2006, 71, 1330.

57. "A Chiral Ag-Based Catalyst for Practical, Efficient, and Highly Enantioselective Additions of Enolsilanes to -Ketoesters" Akullian, Laura C.; Snapper, Marc L.; Hoveyda, Amir H. J. Am. Chem. Soc. 2006, 128, 6532.

58. "Solvent-Controlled Intramolecular [2 + 2] Photocycloadditions of -Substituted Enones" Ng, Stephanie, M.; Bader, Scott J.; Snapper, Marc L. J. Am. Chem. Soc. 2006, 128, 7315.

59. "Preparation of aliphatic ketones through a ruthenium-catalyzed tandem cross-metathesis/allylic alcohol isomerization" Finnegan, David; Seigal, Benjamin A.; Snapper, Marc L. Org. Lett. 2006, 8, 2603.

60. "Enantioselective silyl protection of alcohols catalysed by an amino-acid-based small molecule" Zhao, Yu; Rodrigo, Jason; Hoveyda, Amir H.; Snapper, Marc L. Nature 2006, 443, 67.

61. "Ruthenium-Catalyzed Tandem Olefin Metathesis-Oxidations" Scholte, Andrew A.; Snapper, Marc L. Org. Lett. 2006, 8, 4759.

62. "Functionalized Oxepines via Fragmentation of Highly Strained Epoxides" Leyhane, Andrew J.; Snapper, Marc L. Org. Lett. 2006, 8, 5183.

63. "Conformationally Restricted (+)-Cacospongionolide B Analogues. Influence on Secretary Phospholipase A2 Inhibition" Murelli, Ryan P.; Cheung, Atwood K; Snapper, Marc L. J. Org. Chem. 2006, 72, 1545.

64. "A Highly Efficient and Practical Method for Catalytic Asymmetric Vinylogous Mannich (AVM) Reactions" Carswell, Emma L.; Snapper, Marc L.; Hoveyda, Amir H. Angew. Chem. Int. Ed. 2006, 45, 7230.

65. "Intramolecular Cyclobutadiene Cycloaddition/Cyclopropanation/Thermal Rearrangement: An Effective Strategy for the Asymmetric Syntheses of Pleocarpenene and Pleocarpenone" Williams, Michael J.; Deak, Holly L.; Snapper, Marc. L. J. Am. Chem. Soc. 2007, 129, 486.

66. "Conjugated Ruthenium- Catalyzed Tandem Cross-Metathesis/Wittig Olefination: Generation of Conjugated Dienoic Esters from Terminal Olefins" Murelli, Ryan P.; Snapper, Marc L. Org. Lett.2007, 9, 1749.

67. "Conformationally Restricted (+)- Cacospongionolide B Analogues. Influence on Secretary Phospholipase A2 Inhibition." Murelli, Ryan P.;Cheung, Atwood K.;Snapper, Marc L.. J. Org. Chem. 2007, 72, 1545.

68. "Selective synthesis of ent-15-epi-F2t-isoprostane and a deuterated derivative." Shizuka, Manami; Snapper, Marc L.. Synthesis. 2007, 15, 2397

69. "Kinetic resolution of 1,2-diols through highly site - and enantioselective catalytic silylation" Zhao, Yu; Mitra, Aupron W.; Hoveyda, Amir H,; Snapper, Marc L.. Angew. Chem. Int. Ed. 2007, 46,8471

70. "A Cross-Metathesis Route to the 5-F2-Isoprostanes." Pandya, Bhaumik A.; Snapper, Marc L.. J. Org. Chem. 2008, 73, 3754

71. "Catalytic Asymmetirc Alkylations of Ketoimines. Enantioselective Synthesis of N-Substituted Quaternary Carbon Stereogenic Centers by Zr-Catalyzed Additions of Dialkylzinc Reagents to Aryl-, Alkyl-, and Trifluoroalkyl- Substituted Ketoimines" Fu, Peng; Snapper, Marc L.; Hoveyda, Amir H.. J. AM. Chem. Soc. 2008, 130, 5530.

72. "Catalytic Enantioselective Hosomi-Sakurai Conjugate Allylation of Cyclic Unsaturated Ketoesters" Shizuka, Manami; Snapper, Marc L. Angew. Chem. Int. Ed. 2008, 47, 5049.

73. "Aluminum-Catalyzed Asymmetric Alkylations of
Pyridyl-Substituted Alkynyl Ketones with Dialkylzinc Reagents"
Friel, Donna K.; Snapper, Marc L.; Hoveyda, Amir H. J. Am. Chem. Soc. 2008, 130, 9942.

74. "Three-Component Ag-Catalyzed Enantioselective Vinylogous Mannich and Aza-Diels-Alder Reactions with Alkyl-Substituted Aldehydes" Mandai, Hiroki; Mandai, Kyoko; Snapper, Marc L.; Hoveyda, Amir H. J. Am. Chem. Soc. 2008, 130, 17961.

75. "Ruthenium-catalyzed tandem enyne-cross metathesis–cyclopropanation: three-component access to vinyl cyclopropanes" Murelli, Ryan P.; Catalan, Silvia; Gannon, Michael P.; Snapper, Marc L. Tetrahedron Lett. 2008, 49, 5714.

76. "Catalytic Enantioselective Silylation of Acyclic and Cyclic Triols: Application to Total Syntheses of Cleroindicins D, F, and C" You, Zhen; Hoveyda, Amir H.; Snapper, Marc L. Angew. Chem. Int. Ed. 2009, 48, 547.

77. "Ag-Catalyzed Diastereo- and Enantioselective Vinylogous Mannich Reactions of r-Ketoimine Esters. Development of a Method and Investigation of its Mechanism" Wieland, Laura C.; Vieira, Erika M.; Snapper, Marc L.; Hoveyda, Amir H. J. Am. Chem. Soc. 2009, 131, 570.

78. "A new structural class of S-adenosylhomocysteine hydrolase inhibitors" Kim, Byung Gyu; Chun, Tae Gyu; Lee, Hee-Yoon; Snapper, Marc L. Bioorg. Med. Chem. 2009, 17, 6707.

     
 
Merkert Chemistry Center, Rms 337 & 339
Tel 617.552.1778, and 617.552.3609
email:
snapperlab@bc.edu
Copyright 2002 Marc Snapper Laboratory
Site design & development by Boston College Media Technology Services.