marc snapper laboratory Publications Group Info Research Marc Snapper Home
 
Ilimaquinane
 
cyclobutadiene cycloadditions with imines
 
[2+2+1] Cycloadditions
 
Cacospongionolide B
 
5-8-5 Ring Systems
 
15-F2_Isoprostanes
 
5-7 Ring Systems
 
5-F2-Isoprostanes
 
Tandem Methathesis Olefin Isomerization
 
Catalytic Asymmetric Synthesis of Amines
 
 

Research

15-F2-ISOPROSTANE

Researchers - Thomas Schrader, Manami Shizuka

Thomas SchraderThe focus of my  research has been the development of stereodivergent strategies for the syntheses of a wide variety of isoprostane natural products and analogs in order to determine the biological role and cellular targets of these highly active biomolecules.  The total synthesis of a naturally occurring eight membered 15-F2-isoprostane library has been accomplished using rac-TBS protected 4-hydroxy cyclopentenone as the starting material.  A ring opening cross metathesis serves as a key transformation.  Reagent controlled asymmetric reactions have been employed to furnish enantiopure diastereomers fromManami Shizuka advanced racemic synthons.  These intermediates are carried on to enantiomerically pure isoprostane natural products in a parallel fashion.

 

 

 

15-F2-Isoprostanes Research

A stereodiversified Isoprostane Library:

 
 
     
 
Merkert Chemistry Center, Rms 337 & 339
Tel 617.552.1778, and 617.552.3609
email:
snapperlab@bc.edu
Copyright 2002 Marc Snapper Laboratory
Site design & development by
Boston College Media Technology Services.