Publications


Independent Publication:

     

  • [29] Cao, M.; Yesilcimen, A.; Wasa, M. Enantioselective Conia-Ene-Type Cyclizations of Alkynyl Ketones through Cooperative Action of B(C6F5)3, N-Alkylamine and a Zn-Based Catalyst. J. Am. Chem. Soc. 2019, doi: 10.1021/jacs.8b13757. [Link]
  •  

    scheme_2018

     

  • [28] Chan, J. Z.‡; Chan, Y.‡; Wasa, M. B(C6F5)3-Catalyzed C–H Alkylation of N-Alkylamines Using Silicon Enolates without External Oxidant. Org. Lett. 2019, 21, 984. [Link]
  •  

    scheme_2018

     

  • [27] Shang, M.‡; Chan, J. Z.‡; Cao, M.; Chan, Y.; Wang, Q.; Cook, B.; Torker, S.; Wasa, M. C–H Functionalization of Amines via Alkene-Derived Nucleophiles through Cooperative Action of Chiral and Achiral Lewis Acid Catalysts: Applications in Enantioselective Synthesis. J. Am. Chem. Soc. 2018, 140, 10593. [Link] 
  •  

    scheme_2018

  • [26] Shang, M.; Cao, M.; Wang, Q.; Wasa, M. Enantioselective Direct Mannich-Type Reaction Catalyzed by Frustrated Lewis Acid/Brønsted Base Complexes. Angew. Chem., Int. Ed. 2017, 56, 13338. [Link]

 

scheme_2018

 

  • [25] Shang, M.; Wang, X.; Koo, S. M.; Youn, J.; Chan, J. Z.; Yao, W.; Hastings, B. T.; Wasa, M. Frustrated Lewis Acid/Brønsted Base Catalysts for Direct Enantioselective α-Amination of Carbonyl Compounds. J. Am. Chem. Soc. 2017, 139, 95. [Link]
  •  

    scheme_2016_2
  • [24] Chan, J. Z.; Yao, W.; Hastings, B. T.; Lok, C. K.; Wasa, M. Direct Mannich-Type Reactions Promoted by Frustrated Lewis Acid/Bronsted Base Catalysts. Angew. Chem., Int. Ed. 2016, 55, 13877. [Link]
  •  

    scheme_2016_1

List of Published Work (Prior to Boston College):

  • [23] He, J.; Wasa, M.; Chan, K. S. L.; Shao, Q.; Yu, J.-Q. Palladium-Catalyzed Transformations of Alkyl C–H Bonds. Chem. Rev. 2016, ASAP.
  • [22] Liu, R. Y.; Wasa, M.; Jacobsen, E. N. Asymmetric Synthesis of Tertiary α-Chloro Esters by Non-Covalent Catalysis. Tetrahedron Lett. 2015, 56, 3428.
  • [21] Wasa, M.; Liu, R. Y.; Roche, S. P.; Jacobsen, E. N. Asymmetric Mannich Synthesis of α-Amino Esters by Anion-Binding Catalysis. J. Am. Chem. Soc. 2014, 136, 12872.
  • [20] Xiao, K. -J.; Lin, D. W.; Miura, M.; Zhu, R. -Y.; Gong, W.; Wasa. M.; Yu, J. -Q. Palladium(II)-Catalyzed Enantioselective C(sp3)–H Activation Using a Chiral Hydroxamic Acid Ligand. J. Am. Chem. Soc. 2014, 136, 8138.
  • [19] Chan, K. S. L.; Wasa, M.; Chu, L.; Laforteza, B.; Miura, M.; Yu, J. -Q. Ligand-Enabled Cross-Coupling of C(sp3)–H Bonds with Arylboron Reagents via Pd(II)/Pd(0) Catalysis. Nature Chem. 2014, 6, 146.
  • [18] Figg, T. M.; Wasa, M.; Yu, J. -Q.; Musaev, J. Understanding the Reactivity of Pd(0)/PR3-Catalyzed Intermolecular C(sp3)–H Bond Arylation. J. Am. Chem. Soc. 2013, 135, 14206.
  • [17] He, J.; Wasa, M.; Chan, K. S. L.; Yu, J. -Q. Palladium(0)-Catalyzed Alkynylation of C(sp3)–H Bonds. J. Am. Chem. Soc. 2013, 135, 3387.
  • [16] Wasa, M.; Chan, K. S. L.; Zhang, X.-G.; Miura, M.; Yu, J. -Q. Ligand-Enabled Methylene C(sp3)–H Bond Activation with a Pd(II) Catalyst. J. Am. Chem. Soc. 2012, 134, 18570.
  • [15] Zhang, X.-G.; Dai, H.; Wasa, M.; Yu, J. -Q. Pd(II)-Catalyzed Ortho Trifluoromethylation of Arenes and Insights into the Coordination Mode of Acidic Amide Directing Groups. J. Am. Chem. Soc. 2012, 134, 11948.
  • [14] Wasa, M.; Chan, K. S. L.; Yu, J. -Q. in Asymmetric Synthesis - The Essentials II (Eds.: Christmann, M., Bräse, S.), Wiley-VCH, Weinheim, 2012, 267.
  • [13] Engle, K. M.; Mei, T. -S.; Wasa, M.; Yu, J. -Q. Weak Coordination as a Powerful Means for Developing Broadly Useful C–H Functionalization Reactions. Acc. Chem. Res. 2011, 45, 788.
  • [12] Wasa, M.; Engle, K. M.; Lin, D.; Yoo, E. J.; Yu, J. -Q. Pd(II)-Catalyzed Enantioselective C–H Activation of Cyclopropanes. J. Am. Chem. Soc. 2011, 133, 19598.
  • [11] Wasa, M.; Chan, K. S. L.; Yu, J. -Q. Pd(II)-catalyzed Cross-coupling of C(sp2)–H Bonds and Alkyl–, Aryl–, and Vinyl–Boron Reagents via Pd(II)/Pd(0) Catalysis. Chem. Lett. 2011, 40, 1004.
  • [10] Chan, K. S. L.; Wasa, M.; Wang, X.; Yu, J. -Q. Palladium(II)-Catalyzed Selective Monofluorination of Benzoic Acids Using a Practical Auxiliary: A Weak-Coordination Approach. Angew. Chem. Int. Ed. 2011, 50, 9081.
  • [9] Yoo, E. J.; Wasa, M.; Yu, J. -Q. Pd(II)-Catalyzed Carbonylation of C(sp3)−H Bonds: A New Entry to 1,4-Dicarbonyl Compounds. J. Am. Chem. Soc. 2010, 132, 17378.
  • [8] Wasa, M.; Engle, K. M.; Yu, J. -Q. Cross-Coupling of C(sp3)–H Bonds with Organometallic Reagents via Pd(II)/Pd(0) Catalysis. Isr. J. Chem. 2010, 50, 605.
  • [7] Wasa, M.; Engle, K. M.; Yu, J. -Q. Pd(II)-Catalyzed Olefination of sp3 C−H Bonds. J. Am. Chem. Soc. 2010, 132, 3680.
  • [6] Wasa, M.; Yu, J. -Q. Amide-Directed Arylation of sp3 C–H Bonds using Pd(II) and Pd(0) Catalysts. Tetrahedron 2010, 66, 4811.
  • [5] Wasa, M.; Worrell, B. W.; Yu, J. -Q. Pd(0)/PR3-Catalyzed Arylation of Nicotinic and Isonicotinic Acid Derivatives. Angew. Chem. Int. Ed. 2010, 49, 1275.
  • [4] Wasa, M.; Engle, K. M.; Yu, J. -Q. Pd(0)/PR3-Catalyzed Intermolecular Arylation of sp3 C−H Bonds. J. Am. Chem. Soc. 2009, 131, 9886.
  • [3] Wasa, M.; Yu, J. -Q. Synthesis of β-, γ-, and δ-Lactams via Pd(II)-Catalyzed C−H Activation Reactions. J. Am. Chem. Soc. 2008, 130, 14058.
  • [2] Wang, D. -H.; Wasa, M.; Giri, R.; Yu, J. -Q. Pd(II)-Catalyzed Cross-Coupling of sp3 C−H Bonds with sp2 and sp3 Boronic Acids Using Air as the Oxidant. J. Am. Chem. Soc. 2008, 130, 7190.
  • [1] Giri, R.; Wasa, M.; Breazzano, S. P.; Yu, J. -Q. Converting gem-Dimethyl Groups into Cyclopropanes via Pd-Catalyzed Sequential C−H Activation and Radical Cyclization. Org. Lett. 2006, 8, 5685.


Wasa Research Group

Merkert Center, Boston College, 2609 Beacon Street, Chestnut Hill, MA 02467-3860
wasa@bc.edu  617-552-4311

Copyright © Wasa Research Group 2016